1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-甲基-4-苯基-1,2,3,6-四氢吡啶

CAS 28289-54-5 MFCD00006120

化学结构图

28289-54-5
SMILES: CN1CC=C(CC1)C1C=CC=CC=1

化学属性

Mol. FormulaC12H15N
Mol. Weight173
Boiling Point128-132 °C/12 mmHg(lit.)

别名和识别编码

Chemical Name1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
CAS Number28289-54-5
Synonym MPTP NSC 139654 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine
MDL NumberMFCD00006120
EC Number248-939-7
Chemical Name Translation1-甲基-4-苯基-1,2,3,6-四氢吡啶
Beilstein Registry Number0133712
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Aromatics
  • Heterocycles
  • Neurochemicals
  • {SA} Building Blocks, C12, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

产品应用

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

相关文献及参考

  • Burns, R.S., et al.: Proc. Natl. Acad.Sci. USA, 80, 4546 (1983),
  • Langston, J.W., et al.: Science, 219, 979 (1983),
  • Mogi, M., et al.: Neurosci. Lett., 250, 25 (1998),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P301+P310
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P307+P311
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H301 Toxic if swallowed 吞食有毒
RTECSUT8358900
Signal word Danger 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   55HAAX "MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Papers
   Presented at a Symposium, Bethesda, MD, 1985," Markey, S.P., et al., eds.,
   Orlando, FL, Academic Press, Inc., 1986  Volume(issue)/page/year: -,571,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 50 mg/kg
SEX/DURATION            : female 1-20 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   217,211,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25200 ug/kg
SEX/DURATION            : female 9-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   ANPTAL Acta Neuropathologica.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1961-
   Volume(issue)/page/year: 79,279,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 34 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   ANPTAL Acta Neuropathologica.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1961-
   Volume(issue)/page/year: 79,279,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 375 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
                          female 20 week(s) after conception
TOXIC EFFECTS :
   Repr

系列性分类

  1. C6 to C7 - Pyridines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

相关产品推荐