2-(Trimethylsilyl)ethanol 2-三甲基硅基乙醇

CAS 2916-68-9 MFCD00002825

化学结构图

2916-68-9
SMILES: C[Si](C)(C)CCO

化学属性

Mol. FormulaC5H14OSi
Mol. Weight118.25
Boiling Point145°C at 760 mmHg
Density0.825
Refractive index1.4230 to 1.4250
Flash Point56°C
TSCANo
Solubility可溶

别名和识别编码

Chemical Name2-(Trimethylsilyl)ethanol
CAS Number2916-68-9
Alfabeta NameTRIMETHYLSILYLETHANOL 2-
MDL NumberMFCD00002825
Synonym (2-Hydroxyethyl)trimethylsilane {LY} (2-Hydroxyethyl)trimethylsilane {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} { {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (2-Hydroxyethyl)trimethylsilane
EC Number220-844-5
Beilstein Registry Number1732034
PubChem Substance ID87577204
Reaxys-RN1732034
Chemical Name Translation2-三甲基硅基乙醇
InChIKeyZNGINKJHQQQORD-UHFFFAOYSA-N
Wiswesser Line NotationQ2-SI-1&1&1
LabNetwork Molecule IDLN00009690
InChIInChI=1S/C5H14OSi/c1-7(2,3)5-4-6/h6H,4-5H2,1-3H3
Canonical SMILESC[Si](CCO)(C)C
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分类

  • {SNA} Chemical Synthesis, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents
  • {uni_hamburg} no charge; alcohol; 1fragment

产品应用

  • 经由相关异氰酸酯的醇解，合成Teoc-protected 胺。也是羧基和磷酸根基团的保护试剂。

相关文献及参考

  • Beilstein:4(4)3951
  • Short: III/35F
  • Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).
  • Short: EINECS

安全信息

Warnings FLAMMABLE
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R10 Flammable 易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSKM5480000
Packing GroupIII
UN Number 1987 1993
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class3 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1122 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DANKAS Doklady Akademii Nauk SSSR.  Proceedings of the Academy of Sciences
   of the USSR.  For English translation, see DBIOAM and DKBSAS.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-    1933-
   Volume(issue)/page/year: 229,1011,1976

其他信息

  • MOL 文件:2916-68-9.mol
  • 溶于水。
  • Hazard Note:Flammable
  • 2-(三甲硅基)乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 5ML 559元 2014/06/02 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 25ML 1710元 2010/06/21 210480500 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 99% 50 ML 5354元
  • Alfa Aesar:2-(三甲基硅基)乙醇,98+% 2-(Trimethylsilyl)ethanol, 98+%(2916-68-9)
  • 图谱信息:2-(三甲硅基)乙醇(2916-68-9)质谱(MS) 2-(三甲硅基)乙醇(2916-68-9)核磁图( 1 HNMR) 2-(三甲硅基)乙醇(2916-68-9)红外图谱(IR1) 2-(三甲硅基)乙醇(2916-68-9)核磁图( 13 CNMR)
  • MSDS 信息:2-(Trimethylsilyl)ethanol(2916-68-9).msds
  • TCI Shanghai:2-三甲基硅基乙醇 2-(Trimethylsilyl)ethanol,>;95.0%(GC)(2916-68-9)
  • TSCA:No
  • Acros Organics:2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol, 99%(2916-68-9)
  • 用途一:经由相关异氰酸酯的醇解，合成Teoc-protected 胺。也是羧基和磷酸根基团的保护试剂。
  • 2-(三甲硅基)乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 5ML 862元 2011/04/16 T1441 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 25ML 2630元 2010/06/21 210480500 2-(三甲硅基)乙醇 2-(Trimethylsilyl)ethanol 99% 50 ML 5354元
  • Sigma Aldrich:2916-68-9(sigmaaldrich)
  • 海关编码:29310095

系列性分类

  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Protecting and Derivatizing Reagents - Protection and Derivatization
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Protecting and Derivatizing Reagents - Protection and Derivatization
  5. Silicon-Based - Protecting and Derivatizing Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Protecting and Derivatizing Reagents - Protection and Derivatization
  5. Silicon-Based - Protecting and Derivatizing Reagents
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  4. Silanes 硅烷
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Silicon Compounds for Organic Synthesis 硅化合物

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