2,4-Dichloro-5-fluoropyrimidine 2,4-二氯-5-氟嘧啶

CAS 2927-71-1 MFCD00233551

化学结构图

2927-71-1
SMILES: Fc1cnc(Cl)nc1Cl

化学属性

Mol. FormulaC4HCl2FN2
Mol. Weight166.97
Melting Point37-41°C
Flash Point106°C
TSCANo
Boiling Point222.8°C at 760 mmHg
Density1.422
Stability对湿度敏感

别名和识别编码

Chemical Name2,4-Dichloro-5-fluoropyrimidine
CAS Number2927-71-1
Alfabeta NameDICHLOROFLUOROPYRIMIDINE 245---,
MDL NumberMFCD00233551
Synonym 2,4-Dichloro-5-fluoropyrimidine {LY} 2,4-Dichloro-5-fluoropyrimidine {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,4-Dichloro-5-fluoropyrimidine {} {} {} {}
PubChem Substance ID250705
Reaxys-RN607964
Beilstein Registry Number23(5)5,346
EC Number250-023-7
Chemical Name Translation2,4-二氯-5-氟嘧啶
LabNetwork Molecule IDLN00007632
InChIInChI=1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
Canonical SMILESFC1=CN=C(Cl)N=C1Cl
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分类

  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Heterocycles, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Other Fluorinated Heterocycles, Pyrimidines
  • Building Blocks, C4 to C5, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Heterocycles, Heterocyclic Building Blocks, Heterocyclic Fluorinated Building Blocks, Other Fluorinated Heterocycles, Pyrimidines

产品应用

  • Used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.

相关文献及参考

  • Berge., et al.: J. Pharm. Sci., 66, 1

安全信息

Warnings LACHRYMATOR, CORROSIVE, AVOID SKIN CONTACT
WGK Germany3
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P301+P330+P331
  • P302+P361+P354
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
Hazard Codes 8 C Xi
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen 0-10 0-10°C Moisture Sensitive {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under n
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
UN Number 3261
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII

其他信息

  • 用途一:抗真菌药物氟胞嘧啶的中间体。
  • 2,4-二氯-5-氟嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D3374 2,4-二氯-5-氟嘧啶 2,4-Dichloro-5-fluoropyrimidine 5G 1370元 2014/06/02 D3374 2,4-二氯-5-氟嘧啶 2,4-Dichloro-5-fluoropyrimidine 25G 4840元 2010/05/25 H26288 5-氟-2,4-二氯嘧啶, 98% 5-Fluoro-2,4-dichloropyrimidine, 98% 5g 4130元
  • 上游原料:N,N-二甲基苯胺 --> 5-氟脲嘧啶
  • MOL 文件:2927-71-1.mol
  • 方法一:由5-氟脲嘧啶氯化而得。将5-氟脲嘧啶和三氯氧磷投入氯化锅，搅拌冷却至20℃以下，滴加N，N-二甲基苯胺，滴毕，缓缓升温至110℃，搅拌反应2h，冷至室温。将反应物加至饱和盐水和碎冰中冰解，温度维持15℃搅拌1h，甩滤，水洗，干燥，得成品。
  • 存储注意事项:湿度敏感
  • Hazard Note:Irritant
  • Alfa Aesar:5-氟-2,4-二氯嘧啶,98% 5-Fluoro-2,4-dichloropyrimidine, 98%(2927-71-1)
  • 下游产品:5-氟胞嘧啶
  • Sigma Aldrich:2927-71-1(sigmaaldrich)
  • TCI Shanghai:2,4-二氯-5-氟代嘧啶 2,4-Dichloro-5-fluoropyrimidine,>;98.0%(GC)(2927-71-1)
  • 检测方法:HPLC,NMR

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C4 to C5 - Pyrimidines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Fluorinated Building Blocks 氟化物砌块
  4. Heterocyclic Fluorinated Building Blocks - Fluorinated Building Blocks
  5. Other Fluorinated Heterocycles - Heterocyclic Fluorinated Building Blocks
  6. Pyrimidines - Other Fluorinated Heterocycles

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