17Α-Hydroxyprogesterone Acetate 17α-羟基孕酮醋酸酯

CAS 302-23-8 MFCD00021156

化学结构图

302-23-8
SMILES:

化学属性

Mol. FormulaC23H32O4
Mol. Weight372.50
Appearance 白色粉末，熔点240-245℃。
Melting Point249-250°C
Boiling Point490.2°C at 760 mmHg
Flash Point211.6°C

别名和识别编码

Chemical Name17Α-Hydroxyprogesterone Acetate
Synonym 17α-Acetoxy-4-pregnene-3,20-dione 17α-Acetoxyprogesterone 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate 4-Pregnen-17α-ol-3,20-dione acetate 17-(Acetyloxy)pregn-4-ene-3,20-dione 17-ap 17-α-羟基孕酮 17-乙酸-17-ALPHA-羟基孕酮 17A-HYDROXYPROGESTERONE 17-ACETATE 17a-Hydroxy-4-pregnene-3,20-dione acetate 17α-Acetoxy-4-pregnene-3, 20-dione 17α-Acetoxyprogesterone 17α-Hydroxy-4-pregnene-3, 20-dione 17-acetate 4-Pregnen-17α-ol-3, 20-dione acetate 17α-Acetoxy-4-pregnene-3,20-dione 17α-Acetoxyprogesterone 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate 4-Pregnen-17α-ol-3,20-dione acetate 17α-Hydroxylprogesterone acetate 17α-Hydroxyprogesterone acetate (Megestrol Acetate Impurity) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00021156
PubChem Substance ID24890745
Beilstein Registry Number2227870
EC Number206-119-6
CAS Number302-23-8
Chemical Name Translation17α-羟基孕酮醋酸酯
Wiswesser Line NotationL E5 B666 OV MUTJ A1 E1 FV1 FOV1
LabNetwork Molecule IDLN00874212
Canonical SMILESCC([C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
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安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
RTECSTU5074000
Signal word Warning
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
UN Number UN 2811 6.1/PG 2 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 80500 ug/kg
SEX/DURATION            : female 23 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 105,23,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 896 mg/kg
SEX/DURATION            : female 32 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 105,23,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   ACEDAB Acta Endocrinologica, Supplementum (Copenhagen).  (Periodica,
   Skolegade 12 E, DK-2500 Valby, Denmark)  No.1-    1948-
   Volume(issue)/page/year: 73,17,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   13OPAL "Con

Storage condition 2-8°C

其他信息

  • Sigma Aldrich:302-23-8(sigmaaldrich)
  • MOL 文件:302-23-8.mol
  • 用途二:孕激素类药。
  • 用途一:用作甾体激素药中间体

系列性分类

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