2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione 2-(3-吡啶基甲基)-1H-茚-1,3(2H)-二氧乙烯

CAS 31083-55-3 MFCD31083553

化学结构图

31083-55-3
SMILES:

化学属性

Mol. FormulaC15H9NO2
Mol. Weight235.25

别名和识别编码

Wiswesser Line NotationL56 BVYVJ CU1- CT6NJ
Chemical Name2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
Synonym 1,3-Dioxo-2-(3-pyridylmethylene)indan
CAS Number31083-55-3
Beilstein Registry Number1530546
Chemical Name Translation2-(3-吡啶基甲基)-1H-茚-1,3(2H)-二氧乙烯
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相关文献及参考

  • [1]. Ismail IH, et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288(37):26944-54.

安全信息

RTECSNK6710000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 313,481,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 313,481,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 80 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 313,481,1980

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. E1/E2/E3 Enzyme  (E1/E2/E3泛素酶)

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