L-(+)-Selenomethionine L-硒代蛋氨酸

CAS 3211-76-5 MFCD00037210

化学结构图

3211-76-5
SMILES: C[Se]CC[C@H](N)C(=O)O

化学属性

Mol. FormulaC5H11NO2Se
Mol. Weight196.11
Density1.422
Melting Point265 °C
SolubilitySoluble in water (50 mg/ml).
Appearance powder
Refractive index18 ° (C=0.5, 2mol/L HCl)
Stability热和湿度敏感
Boiling Point320.8±37.0 °C at 760 mmHg

别名和识别编码

Chemical NameL-(+)-Selenomethionine
Synonym L-SelenoMethionine {LY} L-SelenoMethionine {} {LY} L-SelenoMethionine {} {} {LY} L-SelenoMethionine {} {} {} {LY} L-SelenoMethionine {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-SelenoMethionine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00037210
CAS Number3211-76-5
EC Number250-023-7
Beilstein Registry Number2410901
PubChem Substance ID105024
Reaxys-RN2410901
Merck Number8441
Chemical Name TranslationL-硒代蛋氨酸
LabNetwork Molecule IDLN00191065
InChIInChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
Canonical SMILESO=C(O)[C@@H](N)CC[Se]C
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分类

  • {SNA} Allium cepa (Onion), Antioxidant, Antioxidant and Free Radical Scavengers, Cell Stress, Chemopreventive Agents, Functional Foods, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents, Phytochemicals by Plant (Food/Spice/Herb), 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 营养研究
  • {SNA} Allium cepa (Onion), Antioxidant, Antioxidant and Free Radical Scavengers, Bioactive Small Molecules, Cell Signaling and Neuroscience, Cell Stress, Chemopreventive Agents, Functional Foods, Nitric Oxide and Cell Stress, Nutrition Research, Oxidative Stress Proteins and Reagents,
  • {SNA} Alli
  • {SNA} Allium cepa (Onion),

产品应用

  • A compound shown to increase expression of glutathione peroxidase

相关文献及参考

  • [2]. Menter DG, et, al. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1171-82.
  • [3]. Jornot L, et, al. Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells. Biochem J. 1995 Mar 1;306 ( Pt 2)(Pt 2):581-7.
  • [4]. Nuth M, et, al. Mitigating effects of L-selenomethionine on low-dose iron ion radiation-induced changes in gene expression associated with cellular stress. Oncol Lett. 2013 Jul;6(1):35-42.
  • [5]. Guan J, et, al. Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res. 2004 Nov;162(5):572-9.
  • Short: III/35G Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Selenium-77 Author: Duddeck, H. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35G Year: 2004 Keyword: chemical shift; coupling constant; molecular structure ISBN: 3-540-21434-8 I

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S20/21 When using do not eat, drink or smoke 使用时，不得进食，饮水或吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R50/53
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P302+P350
  • P305+P351+P338
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301+H331
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H331 Toxic if inhaled 吸入中毒
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H301 Toxic if swallowed 吞食有毒
RTECSEK7713840
Hazard Codes 6.1 T,N
UN Number 3283 UN 3283 6.1/PG 2
Storage condition 2-8°C {LY} 2-8°C <0°C <;0 {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupII
Hazard Class6.1

其他信息

  • TCI Shanghai:L-硒代蛋氨酸 L-Selenomethionine,>;98.0%(T)(3211-76-5)
  • 用途一:可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定
  • MOL 文件:3211-76-5.mol
  • 比旋光度:18 ° (c=1, 1N HCl)
  • Sigma Aldrich:3211-76-5(sigmaaldrich)
  • L-Selenomethionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine.
  • 上游原料:乙醇 --> 氢氧化钠 --> 盐酸 --> 甲醇 --> 乙醚 --> 硫酸 --> 四氢呋喃 --> 钠 --> N,N-二甲基甲酰胺 --> 氯化钠 --> 丙酮 --> 氨 --> 碳酸氢钠 --> 苯 --> 过氧化氢 --> 碘甲烷 --> 氢溴酸 --> 镁 --> 苄基氯 --> 五氧化二磷 --> 硒 --> 硼酸三丁酯 --> L-蛋氨酸 --> 甲基锂
  • color:white to off-white
  • F:10
  • (S)-(+)-2-氨基-4-(甲基硒)丁酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 S0442 L-硒代蛋氨酸 L-Selenomethionine 5G 7030元 2014/06/02 S0442 L-硒代蛋氨酸 L-Selenomethionine 1G 1910元 2010/06/21 259960010 (S)-(+)-2-氨基-4-(甲基硒)丁酸 L(+)-Selenomethionine 99+%, ee 99+% 1 GR 8260元
  • Acros Organics:L(+)硒代蛋氨酸 L(+)-Selenomethionine, ee 99+%, 99+%(3211-76-5)
  • MSDS 信息:L-(+)-Selenomethionine(3211-76-5).msds

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Chemopreventive Agents - Cancer Research
  4. Antioxidant and Free Radical Scavengers - Chemopreventive Agents
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Functional Foods - Nutrition Research
  4. Antioxidant - Functional Foods
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium cepa (Onion) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  4. Other Amino Acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Amino acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Other Peptides
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Amino acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Cell Stress
  6. Mitochondrial Inhibitors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Kinases and Phosphatases
  6. Protein Kinase Inhibitors and Related Products
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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