TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   MTAEEB Medical Toxicology and Adverse Drug Experience.  (Adis International
   Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.)  V.4-    1989-
   Volume(issue)/page/year: 4,295,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,414,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 286 mg/kg/36H-I
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   MTAEEB Medical Toxicology and Adverse Drug Experience.  (Adis International
   Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.)  V.4-    1989-
   Volume(issue)/page/year: 4,295,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 228 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc.