4-ESTREN-3ALPHA,17BETA-DIOL
CAS 35950-87-9 MFCD00271605
化学结构图
SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=C[C@H](O)CC[C@@H]43)[C@@H]1CC[C@@H]2O
化学属性
| Mol. Formula | C18H28O2 |
|---|---|
| Mol. Weight | 276.41 |
| Melting Point | 203-207 °C |
别名和识别编码
| Chemical Name | Estren |
|---|---|
| Synonym | 4-Estren-3α,17β-diol 4-Estren-3α,17β-diol |
| MDL Number | MFCD00271605 |
| CAS Number | 35950-87-9 |
| PubChem Substance ID | 329756358 |
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分类
- {SNA} Cytokines, Growth Factors and Hormones, Estrogen Modulators, Hormones, Other Steroid Products, Steroid Hormones, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节
- {SNA} Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen Modulators, Hormones, Other Steroid Products, Steroid Hormones, Tumor Growth Regulation
- Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen Modulators, Hormones, Other Steroid Products,
相关文献及参考
- 1. Kousteni, S., et al. Science 298 , 843-846, (2002) 摘要
- 2. Krishnan, V., et al., The Nongenotropic Synthetic Ligand 4-Estren-3{alpha}17{beta}-diol Is a High-Affinity Genotropic Androgen Receptor Agonist Mol. Pharmacol. 67 , 744-748, (2005) 摘要
- 3. Cordey, M., et al., The synthetic estrogen 4-estren-3α,17β-diol (estren) induces estrogen-like neuroprotection Neurobiol. Dis. 19 , 331-339, (2005) 摘要
- 4. Windahl, S.H. et al., Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. J. Clin. Invest. 116 , 2500-2509, (2006) 摘要
- Hewitt, S.C. et al., Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus. Endocrinology 147 , 2203-2214, (2006) 摘要
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