α-Ecdysone α-蜕皮素

CAS 3604-87-3 MFCD00042683

化学结构图

3604-87-3
SMILES: C[C@H]([C@H](O)CCC(C)(C)O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C

化学属性

Mol. FormulaC27H44O6
Mol. Weight464.63
Melting Point242°C

别名和识别编码

Chemical Nameα-Ecdysone
Synonym (2B,3B,5B,22R)-2,3,14,22,25-五羟基胆甾-7-烯-6-酮 (2b,3b,5b,22R)-2,3,14,22,25-Pentahydroxycholest-7-en-6-one Α-蜕皮甾酮(2Β,3Β,5Β,22R)-2,3,14,22,25-五羟基胆甾醇-7烯-6酮 2,3,14,22,25-pentahydroxy-,(2-beta,3-beta,5-beta,22r)-cholest-7-en-6-on Ecdysterone(CyanotisArachnoiseaPe)60%ByHplc ALPHA-ECDYSON 蜕皮松 ECDYSONE, ALPHA- (2Β,3Β,5Β,22R)-2,3,4,20,22,25-六羟基胆甾醇-7-烯-6-酮 2β,3β,14α,22(R),25-五羟基-7-胆甾烯-6-酮 2-beta,3-beta,14,22,25-pentahydroxy-,(20s,22r)-5-beta-cholest-7-en-6-on Β-蜕化激素 2β,3β,14α,22(r),25-pentahydroxy-7-cholesten-6-one (2beta,3beta,5beta,22R)-2,3,14,22,25-pentahydroxycholest-7-en-6-one ALPHA-ECDYSONE 2BETA,3BETA,14ALPHA,22[R],25-PENTAHYDROXY-7-CHOLESTEN-6-ONE 20-羟基蜕化素 ECDYSONE α-蜕皮素 Α-蜕化激素 7,(5-ALPHA)-CHOLESTEN-2-BETA, 3-BETA, 14-ALPHA, 22R, 25-PENTOL-6-ONE -ECDYSONE 98.0% BY HPLC A-ECDYSONE 蜕皮甾酮 β-Ecdysone[20-Hydroxyecdysone] Β-蜕皮甾酮 Α-蜕皮激素 Cholest-7-en-6-one, 2,3,14,22,25-pentahydroxy-, ALPHA-ECDYSTERONE ALPHA-ECYSONE 2β,3β,14α,22(R),25-五羟基-7-胆甾烯-6-酮 Β-蜕皮激素 蜕皮激素; alpha-蜕皮激素; (2b,3b,5b,22R)-2,3,14,22,25-五羟基胆甾-7-烯-6-酮
MDL NumberMFCD00042683
PubChem Substance ID19212
Beilstein Registry Number2422986
CAS Number3604-87-3
EC Number222-760-4
Chemical Name Translationα-蜕皮素
Merck Number13,3525
Wiswesser Line NotationL E5 B666 JUTJ A1 E1 FY1&2YQXQ1&1 IQ OQ PQ
InChIInChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1
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分类

  • Analytical Standards, Analytical/Chromatography, Cell Biology, Cell Signaling and Neuroscience, Chromatography, Cytokines, Growth Factors and Hormones, Environmental Standards, Growth regulators, Hormones, Insecticides, Nutrition Research, Other Steroid Products, Pesticides, Pesticides & Metabolites, Phytochemicals by Chemical Classification, Steroid, Steroid Hormones
  • {SA} Analytical Standards, Analytical/Chromatography, Cell Biology, Cell Signaling and Neuroscience, Chromatography, Cytokines, Growth Factors and Hormones, Environmental Standards,
  • {SNA} Analytical Standards,
  • {SNA} Analytical Stand

相关文献及参考

  • [2]. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225.
  • Beil. 8 ,IV,3613
  • Merck 14 ,3491
  • [1]. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.
  • [1]. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.
  • [2]. Minglei Lu, et al. Activation of Mineralocorticoid Receptor by Ecdysone, an Adaptogenic and Anabolic Ecdysteroid, Promotes Glomerular Injury and Proteinuria Involving Overactive GSK3β Pathway Signaling. Sci Rep. 2018 Aug 15;8(1):12225.

安全信息

WGK Germany3
RTECSFZ8170000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Amphibian - toad
DOSE/DURATION           : 50 mg/kg/17W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   NUCADQ Nutrition and Cancer.  (Franklin Institute Press, POB 2266,
   Phildelphia, PA 19103) V.1-    1978-  Volume(issue)/page/year: 9,103,1987

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 300 umol/L
REFERENCE :
   NNBYA7 Nature (London), New Biology.  (Basingstoke, Hants., UK)  V.229-246,
   1971-73.  For publisher information, see NATUAS.  Volume(issue)/page/year:
   230,222,1971

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 200 ppm
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 30,279,1974

其他信息

  • 用途一:可促进细胞生长，刺激真皮细胞分裂，对人体也有促进蛋白质合成作用
  • MOL 文件:3604-87-3.mol
  • Sigma Aldrich:3604-87-3(sigmaaldrich)
  • F:10

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Steroid - Phytochemicals by Chemical Classification
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Insecticides - Pesticides
  8. Growth regulators - Insecticides
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Insecticides - Pesticides
  8. Growth regulators - Insecticides
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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