2-hydroxyestradiol 2-hydroxyestradiol

CAS 362-05-0 MFCD00010490

化学结构图

362-05-0
SMILES: CC12CCC3c4cc(O)c(O)cc4CCC3C1CCC2O

化学属性

Mol. FormulaC18H24O3
Mol. Weight288

别名和识别编码

Chemical Name2-hydroxyestradiol
CAS Number362-05-0
Synonym 1,3,5(10)-雌甾三烯-2,3-17β-三醇 NSC 61711 雌甾-1,3,5(10)-三烯2,3,17-三醇 2,3,17?-Trihydroxyestra-1,3,5(10)-triene (17?)-Estra-1,3,5(10)-triene-2,3,17-triol 2-Hydroxyestradiol 2-OH-Estradiol 2-羟雌甾二醇 NSC 61711 1,3,5(10)-雌甾三烯-2,3-17β-三醇 雌甾-1,3,5(10)-三烯2,3,17-三醇 Estra-1,3,5(10)-triene-2,3,17?-triol
MDL NumberMFCD00010490
PubChem Substance ID247304
Chemical Name Translation2-hydroxyestradiol
Beilstein Registry Number2219367
LabNetwork Molecule IDLN01292719
InChIInChI=1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Estrogen, H, Hormones, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, H, Hormones, Steroid Hormones
  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, H, Hormones, Steroid Hormones, 细胞生物学
  • {SNA} Bioactive Small Molecules, Cell Bi

产品应用

  • A metabolite of Estradiol.

相关文献及参考

  • Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985),
  • Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991),
  • Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998),
  • Rose, J., et al., The Effects Of Estradiol And Catecholestrogens On Uterine Glycogen Metabolism In Mink (Neovison Vison). Theriogenology 75 , 857-66, (2011) 摘要

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word Warning
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
Hazard Codes Xn
RTECSKG7675000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 储存温度-20°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 42,165,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1280 ng/kg
SEX/DURATION            : male 8 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Endocrine - androgenic
REFERENCE :
   ANDRDQ Andrologia.  (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
   Berlin 30, Fed. Rep. Ger.) V.6-    1974-  Volume(issue)/page/year:
   23,339,1991

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Estrogen - Steroid Hormones

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