1Ah-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide 1AH-二苯并[b,f]环氧乙烯并[2,3-d]氮杂卓-6(10bH)-甲酰胺

CAS 36507-30-9 MFCD00467137

化学结构图

36507-30-9
SMILES: NC(=O)N1C2C=CC=CC=2C2OC2C2C=CC=CC1=2

化学属性

Mol. FormulaC15H12N2O2
Mol. Weight252.29

别名和识别编码

Chemical Name1Ah-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide
CAS Number36507-30-9
Synonym GP 49-023 10,11-Epoxycarbamazepine 1a,10b-Dihydro-6H-dibenzo(b,f)oxireno[d]azepine-6-carboxamide Carbamazepine 10,11-oxide 10,11-Dihydro-10,11-epoxycarbamazepine 1a,10b-Dihydro-6H-dibenz(b,f)oxiren(d)azepine-6-carboxamide 1a,10b-Dihdyro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide Carbamazepine 10,11-epoxide
MDL NumberMFCD00467137
PubChem Substance ID24892674
Chemical Name Translation1AH-二苯并[b,f]环氧乙烯并[2,3-d]氮杂卓-6(10bH)-甲酰胺
Beilstein Registry Number1219988
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, C, CA - CG, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Others, Solutions
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, C, CA - CG, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Others, Solutions

产品应用

  • A metabolite of Carbamazepine (C175840).

相关文献及参考

  • Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987),
  • Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005),
  • Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006),
  • Bellucci, G., et al. J. Med. Chem. 30 , 768, (1987) 摘要

安全信息

WGK Germany3
RTECSHQ4430000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 37,12,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 9600 mg/kg
SEX/DURATION            : female 2 week(s) pre-mating
                          female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 279,1237,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 32 gm/kg
SEX/DURATION            : female 2 week(s) pre-mating
                          female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 279,1237,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 19200 mg/kg
SEX/DURATION            : female 2 week(s) pre-mating
                          female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 279,1237,1996

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs of Abuse - Forensic and Veterinary Standards
  6. Chemical Structure - Drugs of Abuse
  7. Others - Chemical Structure
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CA - CG - C
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Azepine 阿西平

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