1-Methyl-4-phenylpyridin-1-ium iodide 1-甲基-4-苯基吡啶离子

CAS 36913-39-0 MFCD00055096

化学结构图

36913-39-0
SMILES: [I-].C[N+]1C=CC(=CC=1)C1C=CC=CC=1

化学属性

Mol. FormulaC12H12IN
Mol. Weight297.13

别名和识别编码

Chemical Name1-Methyl-4-phenylpyridin-1-ium iodide
CAS Number36913-39-0
Synonym 1-Methyl-4-phenylpyridinium Iodide 1-Methyl-4-phenylpyridinium iodide MPP+ Iodide MPP+ iodide
MDL NumberMFCD00055096
PubChem Substance ID24893235
Chemical Name Translation1-甲基-4-苯基吡啶离子
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分类

  • Mutagenesis Research Chemicals
  • Heterocycles
  • Neurochemicals
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters, Others
  • {SNA} Bioactive Small Molecule Alphabetical Index, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters, Other Dopaminergics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.

相关文献及参考

  • [2]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45.
  • [3]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.
  • Marini, A.M. et al.: J, Nat. Cancer Inst., 84, 1582 (1992); Singh, M. et al.: Arch. Biochem. Biophys., 286, 138 (1991); Santiago, M. et al.: J. Neurosci. Meth., 108, 181 (2001);
  • [1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 20
  • [1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301+H311+H331
WGK Germany3
Signal word Danger
RTECSUU6580000
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22300 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 247,531,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 27,723,1993

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Dopaminergics - Neurotransmitters
  8. Others - Dopaminergics
  1. Medical Research Areas
  2. Metabolism
  3. Mitochondrial Metabolism  (线粒体代谢)

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