(S)-Ethyl piperidine-3-carboxylate (S)-3-哌啶甲酸乙酯

CAS 37675-18-6 MFCD00792499

化学结构图

37675-18-6
SMILES: CCOC(=O)C1CNCCC1

化学属性

Mol. FormulaC8H15NO2
Mol. Weight157.21
Density1.043
Refractive index1.4590 to 1.4610
Flash Point76.7°C
Boiling Point102-104 °C at 7 mmHg

别名和识别编码

Chemical Name(S)-Ethyl piperidine-3-carboxylate
Synonym Ethyl (S)-piperidine-3-carboxylate {LY} Ethyl (S)-piperidine-3-carboxylate {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl (S)-piperidine-3-carboxylate {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00792499
CAS Number37675-18-6
Reaxys-RN81696
PubChem Substance ID87573990
EC Number250-023-7
Beilstein Registry Number81696
Chemical Name Translation(S)-3-哌啶甲酸乙酯
Canonical SMILESO=C([C@@H]1CNCCC1)OCC
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分类

  • {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Piperidines

产品应用

  • 用于合成反应：
  • ?DPP-4抑制剂
  • ?JAK2抑制剂
  • ?5 - 羟色胺和去甲肾上腺素再摄取抑制剂
  • ?人力胰蛋白酶抑制剂

相关文献及参考

  • 1. P. Chen, et al., Bioorg. Med. Chem. Lett. 21 , 1880-1886, (2011)
  • 2. M. W. Ledeboer, et al., Bioorg. Med. Chem. Lett. 19 , 6529-6533, (2009)
  • 3. P. V. Fish, et al., Bioorg. Med. Chem. Lett. 19 , 2829-2834, (2009)
  • 4. W. A. Slusarchyk, et al., Bioorg. Med. Chem. Lett. 12 , 3235-3238, (2002)
  • 5. X. Zheng, et al., Chirality 7 , 90-95, (1995) 摘要
  • 6. B. Sezen and D. Sames, J. Am. Chem. Soc. 126 , 13244-13246, (2004)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H318 Causes serious eye damage 严重伤害眼睛
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Storage condition RT, protect from light {LY} RT, protect from light {} {LY} RT, protect from light {} {} {LY} RT, protect from light {} {} {} {LY} RT, protect from light {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protec
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
Risk Statements
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Piperidines - Heterocyclic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块

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