CAS 3930-19-6 MFCD00063401-Streptonigrin from Streptomyces flocculus -LabNovo

Streptonigrin from Streptomyces flocculus

CAS 3930-19-6 MFCD00063401

化学结构图

SMILES: COC1=C(N)C(=O)c2nc(-c3nc(C(=O)O)c(C)c(-c4ccc(OC)c(OC)c4O)c3N)ccc2C1=O

化学属性

Mol. Formula	C25 H22 N4 O8
Mol. Weight	506.464
Density	1.54
Melting Point	No Data Available
Boiling Point

别名和识别编码

Chemical Name	Streptonigrin from Streptomyces flocculus
MDL Number	MFCD00063401
CAS Number	3930-19-6
Synonym	5278 R.P. Bruneomycin Bruneomycin Nigrin NSC 45383 Nigrin Rufochromomycin Rufocromomycine SN Streptonigran Streptonigrin Streptonigrin from Streptomyces flocculus {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALD} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID	5298
Beilstein Registry Number	0599390
EC Number	223-501-8
Chemical Name Translation
Wiswesser Line Notation	T66 BV EV GNJ CO1 DZ H- BT6NJ CZ DR BQ CO1 DO1& E1FVQ
InChI	InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)

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分类

{SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral, Apoptosis and Cell Cycle, Bacteria, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA Repair Regulators, DNA metabolism, Interferes with DNA Synthesis, Mechanism of Action, S, Spectrum of Activity, Toxins and Venoms
{SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral, Apoptosis and Cell Cycle,

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P310

Hazard statements

H300 Fatal if swallowed 吞食致命

RTECSTJ7350000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Hazard Codes T+

Risk Statements

R28 Very toxic if swallowed 吞咽极毒

Storage condition N/A N/A℃ No Data Available 储存温度2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 865 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 12,132,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 ug/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2330 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 12,132,1967

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 12,132,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse

TYPE OF TEST

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 12,234,1964

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 mg/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typ

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rabbit
DOSE/DURATION           : 50 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 69,101,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 600 ug/L
REFERENCE :
   CMMUAO Chemical Mutagens.  Principles and Methods for Their Detection.
   (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  V.1-    1971-
   Volume(issue)/page/year: 9,165,1984

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 334,23,1995

TYPE OF TE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ug/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ug/kg
SEX/DURATION            : female 9 day(

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ug/kg
SEX/DURATION            : female 2 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 250 ug/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 18,215,1967

Streptonigrin from Streptomyces flocculus

CAS 3930-19-6 MFCD00063401

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化学属性

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化学结构图

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