• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Chemical Synthesis, Other Protecting and Derivatizing Reagents, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
• {SNA} Chemical Synthesis, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

• OH-保护试剂. MEM醚在各种反应条件下都很稳定。医药上用作罗红霉素的中间体。

相关文献及参考

• MEM ethers have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereocontrolled addition of ɑ-methoxyvinyllithium to a carbonyl in the synthesis of taxusin: J. Am. Chem. Soc., 110, 6558 (1988), and subsequently in the addition of MeLi to an ɑß-unsaturated sulfone: J. Am. Chem. Soc., 113, 3085 (1991); see 2,2,2-Trifluoroethanol, A10788, for another example.
• For cleavage by PPTS, see: Synth. Commun., 1021 (1983). For cleavage by TMS chloride/ NaI or, less effectively, by preformed TMS iodide, see: Tetrahedron Lett., 25, 1429 (1984).
• For use in the protection of the OH groups in serine and threonine during peptide synthesis, see: Int. J. Pept. Prot. Res., 25, 544 (1985). See also Appendix 6.
• Reagent for the protection of OH groups, in the presence of a base, e.g. NaH in THF or N-Ethyl­diisopropyl­amine, A11801. The MEM-group is more readily and cleanly introduced than methoxymethyl (MOM) and is stable to a wide range of conditions. The MEM group is selectively cleaved by mild Lewis acids, e.g. ZnBr2 or TiCl4: Tetrahedron Lett., 809, 4701, 4705 (1976); 24, 3969 (1983), PPTS: Synth. Commun., 13, 1021 (1983), in situ generated TMS iodide: Tetrahedron Lett., 25, 1429 (1984), or CeCl3: Org. Lett., 3, 1149 (2001).

安全信息

其他信息

• 用途二:用作罗红霉素的中间体。
• 2-甲氧基乙氧基甲基氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0680 2-甲氧乙氧基甲基氯 2-Methoxyethoxymethyl Chloride 25ML 868元 2014/06/02 M0680 2-甲氧乙氧基甲基氯 2-Methoxyethoxymethyl Chloride 500ML 7430元 2010/06/21 185981000 2-甲氧基乙氧基甲基氯 MEM chloride 94% 100 GR 5697元
• 用途三:OH-保护试剂. MEM醚在各种反应条件下都很稳定。医药上用作罗红霉素的中间体。
• 敏感性:Moisture Sensitive
• Sigma Aldrich:3970-21-6(sigmaaldrich)
• Alfa Aesar:2-甲烷氧基乙氧基甲基氯,94% 2-Methoxyethoxymethyl chloride, 94%(3970-21-6)
• 下游产品:罗红霉素
• Hazard Note:Toxic
• MSDS 信息:beta-Methoxyethoxymethyl chloride(3970-21-6).msds
• Acros Organics:B-甲氧基乙氧基甲基氯 MEM chloride, 94%(3970-21-6)
• TCI Shanghai:2-甲氧乙氧基甲基氯 2-Methoxyethoxymethyl Chloride,>;95.0%(GC)(3970-21-6)
• MOL 文件:3970-21-6.mol
• F:10-21
• 用途一:用于生产罗红霉素中间体