2-氨基-1,3,4-噻二唑 2-氨基-1,3,4-噻二唑

CAS 4005-51-0 MFCD00003107

化学结构图

4005-51-0
SMILES: Nc1nncs1

化学属性

Mol. FormulaC2H3N3S
Mol. Weight101.13
Density1.422
Melting Point181-182°C
TSCANo
Appearance 白色结晶。熔点:190-192℃。
Boiling Point238.9°C at 760 mmHg

别名和识别编码

Chemical Name2-氨基-1,3,4-噻二唑
CAS Number4005-51-0
Alfabeta NameTHIADIAZOLYLAMINE 1342[]--,,
MDL NumberMFCD00003107
Synonym 1,3,4-Thiadiazol-2-amine {LY} 1,3,4-Thiadiazol-2-amine {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazo
EC Number223-657-7
Beilstein Registry Number107135
PubChem Substance ID19909
Reaxys-RN107135
Chemical Name Translation2-氨基-1,3,4-噻二唑
Wiswesser Line NotationT5NN DSJ CZ
LabNetwork Molecule IDLN00119552
InChIInChI=1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
Canonical SMILESNC1=NN=CS1
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分类

  • Pharmaceuticals
  • Sulfur & Selenium Compounds,
  • Aromatic
  • Heterocycles
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Thiadiazoles
  • Amines
  • Intermediates & Fine Chemicals

产品应用

  • A thiadiazole derivative with fungacidal properties. An antitumor agent.

相关文献及参考

  • Lu, K. et al.: Cancer Chemother. Pharmacol., 4, 275 (1980); Rauckyte, T. et al.: ECOpole?04, Ksiega Konf./Proc., 139 (2004); Nelson, J.A. et al.: Cancer Res., 36, 1375 (1976);

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P305+P351+P338
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSXI3000000
Packing GroupIII
UN Number 2811
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes 6.1 Xn Xn,Xi
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 35,68,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JHMJAX Johns Hopkins Medical Journal.  (Baltimore, MD)  V.120-151, 1967-82.
   Discontinued.  Volume(issue)/page/year: 130,95,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6500 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 35,68,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 1-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 5,250,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspen

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CPHPA5 Jiepou Xuebao.  Journal of Anatomy.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-9, 1953-66; V.10-
   1979-  Volume(issue)/page/year: 12,212,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF E

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 急性毒性:腹腔-大鼠 LD50: 200 毫克/公斤; 腹腔-小鼠 LD50: 6500 毫克/公斤
  • MSDS 信息:1,3,4-Thiadiazol-2-amine(4005-51-0).msds
  • 储运特性:库房通风低温干燥
  • 毒性分级:高毒
  • Sigma Aldrich:4005-51-0(sigmaaldrich)
  • Alfa Aesar:2-氨基-1,3,4-噻二唑,98+% 2-Amino-1,3,4-thiadiazole, 98+%(4005-51-0)
  • TCI Shanghai:2-氨基-1,3,4-噻二唑 2-Amino-1,3,4-thiadiazole,>;98.0%(T)(4005-51-0)
  • 2-氨基-1,3,4-噻二唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1060 2-氨基-1,3,4-噻二唑 2-Amino-1,3,4-thiadiazole 5G 511元 2014/06/02 A1060 2-氨基-1,3,4-噻二唑 2-Amino-1,3,4-thiadiazole 25G 1360元 2010/06/21 268160100 2-氨基-1,3,4-噻二唑 2-Amino-1,3,4-thiadiazole 97% 10 GR 819元
  • MOL 文件:4005-51-0.mol
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • Acros Organics:2-氨基-1,3,4-噻二唑 2-Amino-1,3,4-thiadiazole, 97%(4005-51-0)
  • 类别:有毒物品
  • 用途一:用于染料、以及唑类药物合成
  • Hazard Note:Harmful
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
  • 用途二:用作医药、染料的中间体

系列性分类


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