2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid 2-(2,3-二氯-4-(噻吩-2-羰基)苯氧基)乙酸

CAS 40180-04-9 MFCD00867339

化学结构图

40180-04-9
SMILES: OC(=O)COC1C=CC(=C(Cl)C=1Cl)C(=O)C1=CC=CS1

化学属性

Mol. FormulaC13H8Cl2O4S
Mol. Weight331

别名和识别编码

Chemical Name2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid
CAS Number40180-04-9
Synonym ######## (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid ANP 3624 CE 3624 Diflurex FR 3068 SKF 62698 Selacryn Thienylic acid Ticrex Ticrynafen Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid Tienilic Acid Tienilic acid Tienilico acido
MDL NumberMFCD00867339
Chemical Name Translation2-(2,3-二氯-4-(噻吩-2-羰基)苯氧基)乙酸
Wiswesser Line NotationT5SJ BVR BG CG DO1VQ
Beilstein Registry Number1260086
EC Number254-826-3
PubChem Substance ID329825452
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分类

  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, New Products, Substrates, Inducers, Inhibitors
  • Sulfur & Selenium Compounds
  • Heterocycles
  • Pharmaceuticals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Intermediates & Fine Chemicals
  • Aromatics

产品应用

  • Tienilic Acid is a heterocyclic derivative of phenoxyacetic acid. Tienilic acid is used as diuretic, uricosuric, antihypertensive.

相关文献及参考

  • Kerremans, A.L., et al.: Eur. J. Clin. Pharmacol., 22, 515 (1982),

安全信息

RTECSAG9300000 
TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3571 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 18,425,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3758506

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 318 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   13,257,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   301,1179,1979

TYPE OF TEST            : TDLo - Lowest published toxic

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 157,1,1985

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 157,1,1985

WGK Germany3
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Multi-Drug Resistance and Drug Metabolism - Cell Signaling and Neuroscience
  5. Drug and Xenobiotic Metabolism - Multi-Drug Resistance and Drug Metabolism
  6. Substrates, Inducers, Inhibitors - Drug and Xenobiotic Metabolism

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