• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Acyclic, Alkenes, Building B
• {SNA} A-B, A-D, Alphabetical Listings, Certified Food Grade Products, Certified Natural Products, Flavors and Fragrances, Kosher Certified Products
• {Chemicalbook} 食品添加剂: 食用香料（增香剂）: 天然等同香料和人造香料
• {SNA} A - D, A-B, Alphabetical Listings,

产品应用

• 己烷雌酚、胆维他的中间体，生产茴香醛的原料。香料、药物制剂辅料等

相关文献及参考

• [2]. Nakagawa Y, et al. Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Jul 1;66(1):63-73.
• [3]. Fahlbusch, et al. "Flavors and Fragrances", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH.
• Merck 14 ,643
• Merck: 14,643
• Merck: 14,643 Beilstein:6,566
• Nakagawa, Y., and Suzuki, T., Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem. Pharmacol. 66 , 63-73, (2003) 摘要
• Short: II/27B
• [1]. Tabanca N, et al. Estrogenic activity of isolated compounds and essential oils of Pim
• [1]. Tabanca N, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med. 2004 Aug;70(8):728-35.

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 286 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,11,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2090 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2167 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 22,309,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 22,309,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3050 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (genera

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ng/plate
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A116-715

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 60,143,1979

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 24 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 326,199,1995

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 49 gm/kg
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,21,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 1-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   IJPPAZ Indian Journal of Physiology and Pharmacology.  (All India Institute
   of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029,
   India)  V.1-    1957-  Volume(issue)/page/year: 39,63,1995

其他信息

• 与乙醚、氯仿互溶，溶于苯、丙酮、乙酸乙酯、二硫化碳，不溶于水。
• 茴香烯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0494 反-茴香脑 trans-Anethole 500G 868元 2014/06/02 P0494 反-茴香脑 trans-Anethole 25G 137元 2010/06/21 152531000 茴香烯 trans-Anethole 99% 100 ML 1545元
• 含量分析:按气相色谱法(GT-10)测定。所用条件为： 柱长160cm，内径2mm，材质为玻璃。填料为聚乙二醇20M(Carbowax 20M)，15%；载体为60/80目硅藻土(Chromosorlb W)，85%。载气为氦，流量50ml/min。检测器用火焰电离型。 进样温度230℃。柱温等温段130℃/3min，温升速度3.5℃/min，终温等温于230℃。 顺式异构体先流出。最后按面积百分率计算含量(包括顺式异构体的百分率)。
• 方法一:茴香脑在工业制法有多种，现介绍以下几种。（1）将茴香油或大茴香油冷却，析出结晶，经蒸馏并用酒精再结晶可得。也可以对茴香油精馏，收集230-234℃的馏了出物。或减压精馏，收集142℃（5.60kPa）或110℃（2.7kPa）馏分，即得茴香脑。（2）由对甲氧基苯基丁烯酸经220-240℃加热而得。（3）将对丙烯基苯甲醚与苛性碱一起加热，异构化为茴香脑。（4）由对丙烯基苯酚甲基化而得。（5）茴香醛与G2H5MgX作用，将生成物加热水脱水得到茴香脑。（6）茴香醛与丙酸酐及丙酸钠一起加热得到茴香脑。（7）在茴香醚和丙醛混合物中，于0℃加入浓盐酸和磷酸，使氯化氢气体达饱和，将产物与吡啶一起加热脱去氯化氢，即得到茴香脑。也可用氢溴酸代替浓盐酸，产物用金属钠处理，脱溴化氢即得到茴香脑。（8）将对溴茴香醚制备成Grignard试剂，并与烯丙基溴反应，生成对甲氧基苯丙烯，然后与氢氧化钾一起加热，异构化得到茴香脑。
• 使用限量:FEMA(mg/kg)：软饮料11；冷饮2溷糖果340；焙烤食品150；
• 方法一:由大茴香脑含量高的精油(如茴香油)单离。 由对甲酚和甲醛反应后再与乙醛缩合而成。
• 急救治疗:制剂：误服者应立即催吐，洗胃。吸入中毒者可用半胱氨酸衍生物，如甲基胱氨酸给病人进行15分钟雾化吸入。神经系
• Sigma Aldrich:4180-23-8(sigmaaldrich)
• 参考质量标准:FCC，1996
• {Chemical
• 图谱信息:茴香烯(4180-23-8)核磁图( 1 HNMR) 茴香烯(4180-23-8)红外图谱(IR1) 茴香烯(4180-23-8)Raman光谱 茴香烯(4180-23-8)红外图谱(IR2) 茴香烯(4180-23-8)核磁图( 13 CNMR) 茴香烯(4180-23-8)质谱(
• 上游原料:茴香脑 --> 小茴香油
• 中毒症状:制剂：可表现为恶心、呕吐、呼吸困难、急促，血压过低、脉搏迟缓，接着出现高血压和心博过快，也可能短时期反应迟钝。然后全身兴奋，严重时有惊厥等现象或症状。
• Sigma Aldrich:104-46-1(sigmaaldrich)
• 参考质量标准:FCC，1996 含量 ≥99.0％(W/W) 醇中溶解度(OT-43) lml溶于2mL 96%乙醇 旋光度 ≤-0.15°～+0.15° 馏程 231～237℃ 酚类试验 正常 凝固点 ≥20℃ 折射率(
• FEMA:2086
• 用途三:主要用于提取茴香脑,也用于配制饮料、食品、烟草等的增香剂以及医药方面。
• 下游产品:对甲氧基苯甲醛 --> 茴三硫 --> 茴香烯 --> 4,4'-(1,2-二乙基亚乙基)二苯酚 --> 1-甲氧-4丙基苯
• 上游原料:氢氧化钠 --> 钠 --> 苯甲醚 --> 对甲氧基苯甲醛 --> 3-溴丙烯 --> 丙酸酐 --> 二甲醚 --> 对苯二甲醚 --> 丙酸钠 --> 巴豆酸 --> 4-溴苯甲醚 --> 4-苯基-1-丁烯 --> 烯丙苯 --> 4-烯丙基苯甲醚 --> 小茴香油 --> 大茴香油