(S)-(-)-Propranolol hydrochloride (S)-(-)-普奈洛尔

CAS 4199-10-4 MFCD00064547

化学结构图

4199-10-4
SMILES: CC(C)NC[C@H](O)COc1cccc2ccccc12.Cl

化学属性

Mol. FormulaC16H22ClNO2
Mol. Weight295.80
Melting Point193-195 °C(lit.)
Appearance powder
Solubilityethanol: 10 mg/mL

别名和识别编码

Chemical Name(S)-(-)-Propranolol hydrochloride
CAS Number4199-10-4
Synonym (S)-(-)-Propranolol (hydrochloride) {LY} (S)-(-)-Propranolol (hydrochloride) {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} (S)-(-)-Propranolol (hydroc
MDL NumberMFCD00064547
PubChem Substance ID165193
EC Number224-096-0
Beilstein Registry Number3574966
Chemical Name Translation(S)-(-)-普奈洛尔
LabNetwork Molecule IDLN01308288
InChIInChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1
Canonical SMILESO[C@H](COC1=C2C=CC=CC2=CC=C1)CNC(C)C.[H]Cl
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分类

  • {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, PI-PZ, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • Pharmaceuticals
  • {SNA} Adrenergics, Adrenergics - Antagonists, Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molec

产品应用

  • The S-enantiomer of Propranolol (P831800). ??Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

相关文献及参考

  • Bond, et al.: Nature, 213, 721 (1967),
  • Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),
  • Hansteen, V., et al.: Br. Med. J., 284, 155 (1982),
  • [1]. Jillian G Baker , et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P312
  • P304+P340
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storag

其他信息

  • MOL 文件:4199-10-4.mol
  • Sigma Aldrich:4199-10-4(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Organic Building Blocks - Chiral Building Blocks
  5. Amino Alcohols - Organic Building Blocks
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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