Vitamin e succinate D-α-生育酚琥珀酸酯

CAS 4345-03-3 MFCD00072055

化学结构图

4345-03-3
SMILES: Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)O)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2

化学属性

Mol. FormulaC33H54O5
Mol. Weight530.78
Melting Point73-77
Density1.002
Stability对热敏感
SolubilitySoluble in DMSO, chloroform (50 mg/ml), and ethanol. Insoluble in water

别名和识别编码

Chemical NameD-α-Tocopherol succinate, 96%, reference material
CAS Number4345-03-3
Synonym D-α-Tocopherol Succinate {LY} D-α-Tocopherol Succinate R,R,R-alpha-Tocopherol Tocopherol Acetate Tocopherol Succinate Tocopherol, d-alpha Tocopheryl Acetate alpha Tocopherol alpha Tocopherol Acetate alpha Tocopherol Hemisuccinate alpha Tocopherol Succinate alpha Tocopheryl Calcium Succinate alpha-Tocopherol alpha-Tocopheryl Calcium Succinate alpha-tocopherol acetate alpha-tocopherol hemisuccinate alpha-tocopherol succinate d alpha Tocopherol d alpha Tocopheryl Acetate d-alpha Tocopherol d-alpha-Tocopheryl Acetate vitamin E succinate {} {LY} D-α-Tocopherol Succinate {} {} {LY} D-α-Tocopherol Succinate {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {LY} D-α-Tocopherol Succinate {} {} {} {} {} {} {LY} D-α-Tocop
MDL NumberMFCD00072055
PubChem Substance ID20353
Beilstein Registry Number4038233
EC Number224-403-8
Chemical Name TranslationD-α-生育酚琥珀酸酯
Merck Number9495
Reaxys-RN65995
LabNetwork Molecule IDLN00196324
InChIInChI=1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1
Canonical SMILESCC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(CCC(O)=O)=O)=C1C)C
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分类

  • {SNA} Antioxidants and Cytoprotectants, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Lipids, Nitric Oxide and Cell Stress, Prenols, T, Vitamin E
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
  • Analytical Standards, Analytical/Chromatography, Chromatography, Fat-Soluble Vitamins, Food & Beverage Standards, Market Segments, Neats and Solutions,
  • {SNA} Antioxidants and Cytoprotectants,
  • {SN

产品应用

  • A potent antioxidant tocopherol

相关文献及参考

  • Weber, T. et al.: Clin. Can Res., 8, 863 (2002);Staphelberg, M. et al.: Biochem. Biophys. Res. Comm., 318, 636 (2004); Ramathapuram, L.V. et al.: Cancer Immunol. Immununother., 55, 166 (2005);
  • Merck 14 ,9495

安全信息

WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSEJ9984000
Storage condition -20°C {LY} -20°C 0-10°C 2-8°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 25,273,1977

GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Hazard statements

其他信息

  • D-α-Tocopheryl Succinate is a potent antioxidant tocopherol. At high concentrations it has been shown to trigger caspase-mediated apoptosis of certain cells and, at low concentrations, inhibit proliferation. Mechanistic studies suggest that this compound down-regulates the fibroblast growth factor receptor-1 (FGFR1). Other experiments report that D-α-Tocopheryl Succinate also targets ASK 1, GADD 45β, and MEK-4, three key components of stress-activated mitogen-activated protein kinase pathway.
  • F:8-10-23
  • MOL 文件:4345-03-3.mol
  • MSDS 信息:D-alpha-Tocopherol succinate(4345-03-3).msds
  • Sigma Aldrich:4345-03-3(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. T - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Prenols - Lipids
  5. Vitamin E - Prenols
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TF - TO - T
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Vitamins - Food & Beverage Standards
  6. Fat-Soluble Vitamins - Vitamins
  7. Vitamin E - Fat-Soluble Vitamins

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