2-(4-Chlorobenzyl)pyridine 2-(4'-氯苄基)吡啶

CAS 4350-41-8 MFCD00006353

化学结构图

4350-41-8
SMILES: Clc1ccc(Cc2ccccn2)cc1

化学属性

Mol. FormulaC12H10ClN
Mol. Weight203.67
Density1.170
Refractive index1.5850 to 1.5880
Flash Point>110°(230°F)
TSCANo
Boiling Point181-183 °C at 20 mmHg
Melting Point8 °C

别名和识别编码

Chemical Name2-(4-Chlorobenzyl)pyridine
MDL NumberMFCD00006353
CAS Number4350-41-8
Synonym 2-(4-Chlorobenzyl)pyridine {LY} 2-(4-Chlorobenzyl)pyridine {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(4-Chlorobenzyl)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number224-412-7
Beilstein Registry Number20(3/4)3650
Reaxys-RN133425
PubChem Substance ID78054
Chemical Name Translation2-(4'-氯苄基)吡啶
InChIKeyXSVWMIMFDMJQRL-UHFFFAOYSA-N
LabNetwork Molecule IDLN01741071
InChIInChI=1S/C12H10ClN/c13-11-6-4-10(5-7-11)9-12-3-1-2-8-14-12/h1-8H,9H2
Canonical SMILESClC1=CC=C(CC2=NC=CC=C2)C=C1
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安全信息

Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 用途一:用作药物扑尔敏的中间体
  • TCI Shanghai:2-(4-氯苄基)吡啶 2-(4-Chlorobenzyl)pyridine,>;98.0%(GC)(4350-41-8)
  • 方法一:由2-氯甲基吡啶与苯胺缩合，再经重氮、置换、消除而得：1.缩合将2-氯甲基吡啶和苯胺加入反应锅，加盐酸至pH=1，浓缩蒸馏去水，至130℃停止蒸馏。升温至220℃反应3h。冷至180℃，将反应液加至热水中，冷却，加碱至pH为12以上，分取油层。水层用甲苯提取。提取液和油层合并，并用水洗至中性，回收甲苯，蒸出苯胺，收集190℃以上馏分，得2-对氨基苄基吡啶。2.重氮、置换、消除将2-对氨基苄基吡啶溶于盐酸，冷至5℃以下。慢慢滴加亚硝酸钠水溶液，温度保持在10℃以下。滴加至反应液对碘化钾淀粉试纸呈紫色。加毕，搅拌半小时，加至氯化亚铜盐酸溶液中，室温搅拌半小时，加氢氧化铵至pH为9以上。加入甲苯中，搅匀后静置，分取甲苯层，水层用甲苯提取，将甲苯液合并，用水洗至中性，回收甲苯后减压蒸馏，得2-对氯苄基吡啶。
  • 2-对氯苄基吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 C1049 2-(4-氯苄基)吡啶 2-(4-Chlorobenzyl)pyridine 25G 204元 2010/05/25 B23170 2-(4-氯苯甲基)吡啶, 97% 2-(4-Chlorobenzyl)pyridine, 97% 25g 258元
  • 用途二:药物中间体。用于生产扑尔敏。
  • MSDS 信息:2-(4-Chlorobenzyl)pyridine(4350-41-8).msds
  • 上游原料:氢氧化铵 --> 氯化亚铜 --> 碘化钾淀粉试纸 --> 2-氯甲基吡啶 --> 4-(2-吡啶甲基)苯胺
  • Alfa Aesar:2-(4-氯苯甲基)吡啶,97% 2-(4-Chlorobenzyl)pyridine, 97%(4350-41-8)
  • MOL 文件:4350-41-8.mol
  • 图谱信息:2-对氯苄基吡啶(4350-41-8)红外图谱(IR1) 2-对氯苄基吡啶(4350-41-8)核磁图( 1 HNMR) 2-对氯苄基吡啶(4350-41-8)质谱(MS) 2-对氯苄基吡啶(4350-41-8)核磁图( 13 CNMR)
  • 下游产品:马来酸氯苯那敏
  • 2-对氯苄基吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1049 2-(4-氯苄基)吡啶 2-(4-Chlorobenzyl)pyridine 25G 237元 2010/05/25 B23170 2-(4-氯苯甲基)吡啶, 97% 2-(4-Chlorobenzyl)pyridine, 97% 25g 258元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶

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