Cis-4-[(4-Chlorophenyl)Sulfonyl]-4-(2,5-Difluorophenyl)Cyclohexanepropanoic Acid 顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸
CAS 471905-41-6 MFCD21608529
化学结构图
SMILES: O=C(O)CC[C@H]1CC[C@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1
化学属性
| Mol. Weight | 442.9 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 顺式-4-[(4-氯苯基)磺酰基]-4-(2,5-二氟苯基)环己烷丙酸 |
|---|---|
| Chemical Name | Cis-4-[(4-Chlorophenyl)Sulfonyl]-4-(2,5-Difluorophenyl)Cyclohexanepropanoic Acid |
| Formula | C21H21ClF2O4S |
| Synonym | Code name: MK0752. Chemical name: cis34(3chlorophenyl)sulfonyl4(25difluorophenyl)cyclohexyl propanoicacid. |
| IUPAC Name | 3-((1r,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid. |
| InChIKey | XCGJIFAKUZNNOR-HNSKJHPRSA-N |
| InChI | InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)/t14-,21- |
| Canonical SMILES | O=C(O)CC[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1 |
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产品应用
- MK0752 is a synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
安全信息
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