(2R,3R)-3,3',4',5,7-Pentahydroxyflavanone 花旗松素

CAS 480-18-2 MFCD00006845

化学结构图

480-18-2
SMILES: O[C@@H]1[C@H](OC2C=C(O)C=C(O)C=2C1=O)C1C=C(O)C(O)=CC=1 |&1:1,2|

化学属性

Mol. FormulaC15H12O7
Mol. Weight304
Density1.702
Melting Point230-233°C (dec.)

别名和识别编码

Chemical Name(2R,3R)-3,3',4',5,7-Pentahydroxyflavanone
MDL NumberMFCD00006845
CAS Number480-18-2
EC Number207-543-4
Beilstein Registry Number5299277
Synonym TAXIFOLIN, (+)- 花旗松素 dihydro-querceti 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on 3,5,7,3',4'-PENTAHYDROXYFLAVANONE 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on( 3,3',4',5,7-PENTAHYDROXYFLAVANONE 4H-1-Benzopyran-4-one, (2R,3R)-二氢槲皮素 2theta-trans)- 2,3-dihydro-3,3’,4’,5,7-pentahydroxy-flavon (+)-DIHYDROQUERCETIN (2R,3R)-二氢槲皮素 (2R,3R)-3,3′,4′,5,7-五羟基黄烷酮 黄杉素 Dihydroquercetin,~99% (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone 5,7,3',4'-四羟基二氢黄酮醇 taxifoliol (+)-3,3',4',5,7-PENTAHYDROXYFLAVANONE (+)-TAXIFOLIN 3,3’,4’,5,7-pentahydroxy-flavanon (2R,3R)-DIHYDROQUERCETIN DIHYDROQUERCETIN distylin TAXIFOLIN 二氢槲皮素 紫杉叶素 (2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
PubChem Substance ID24887336
Chemical Name Translation花旗松素
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分类

  • {SNA} Additional Standards, Alcohols, Alphabetical Index of Phytochemical Standards, Analytical Standards, Aromatic, Aromatics, Chemical Class, Chromatography, Citrus, Equisetum, Flavonoids, Flavonoids (Catechins), Heterocyclics, Ketones, Life Sciences Standards, Natural Compounds, Natural Terpene Standards, Other, Oxygen containing, Phenols, Phytochemical Standards, Phytochemical Standards by Plant Genus, Pinus, Polyhydroxy compounds, S - Z, Salix,
  • {SNA} Ad

相关文献及参考

  • [2]. Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511.
  • [3]. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.
  • [1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586.
  • [1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586.
  • [2]. Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Tax

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSLK6920000
Storage condition 储存温度2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 21,377,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 985 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 38,213,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 gm/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1660 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 54,297,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,401,1981

其他信息

  • MOL 文件:480-18-2.mol
  • 检测方法:NMR,HPLC
  • Sigma Aldrich:480-18-2(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. T - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TA - TE - T
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Medical Research Areas
  2. Metabolism
  3. Tyrosinase  (酪氨酸酶)

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