1-Methyl-9H-pyrido[3,4-b]indole 1-甲基-9H-吡啶并[3,4-b]吲哚

CAS 486-84-0 MFCD00004957

化学结构图

486-84-0
SMILES: Cc1nccc2c1[nH]c1ccccc12

化学属性

Mol. FormulaC12H10N2
Mol. Weight182.22
Melting Point235-238 °C
Boiling Point305.62 °C at 760 mmHg

别名和识别编码

Chemical Name1-Methyl-9H-pyrido[3,4-b]indole
CAS Number486-84-0
Alfabeta NameMETHYLCARBOLINE BETAH19----
MDL NumberMFCD00004957
Synonym Harmane {LY} Harmane {} {LY} Harmane {} {} {LY} Harmane {} {} {} {LY} Harmane {} {} {} {} {LY} Harmane {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID5281404
Beilstein Registry Number0143898
EC Number207-642-2
Chemical Name Translation1-甲基-9H-吡啶并[3,4-b]吲哚
Merck Number13,4630
Wiswesser Line NotationT B656 EN HMJ F
LabNetwork Molecule IDLN00143991
InChIInChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
Canonical SMILESCC1=NC=CC2=C1NC3=C2C=CC=C3
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分类

  • {SNA} Analytical Reagents, Analytical/Chromatography, Mass Spectrometry (MS), Matrix Substances for MALDI-MS, Spectroscopy
  • {SNA} Bioactive Small Molecules, Building Blocks, Carbazoles, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Cichorium intybus (Chicory), Glycan Labeling and Analysis, Glycobiology, H, Heterocyclic Building Blocks, Matricies for Mass Spectroscopy Analysis of Glycans, Neurobiology, Neuroscience, Nutrition Research, Pharmacologicals, Phytochemicals by Plant (Food/Spice/Herb), Post-Translational Modification,
  • {SNA} Mass Spectrometry (MS), Matrix Substances for MALDI-MS,
  • {SNA} Mass Spectrometry (MS),

产品应用

  • Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vu

相关文献及参考

  • [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9.
  • [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications
  • [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.
  • ########
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/35B Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts and Coupling Constants for Fluorine-19 and Nitrogen-15 Author: Balasubramanian, M.; Gupta, R.R.; Jain, M.; Perumal, S. Editor:

安全信息

Warnings IRRITANT
RTECSUV0280000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Packing GroupIII
Hazard Codes Xn
Hazard Class6.1(b)
UN Number 1544
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,164,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg/4W (Continuous)
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   42,179,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   17,249,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 208,39,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,433,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 200 umol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 86,124,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 150 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam,

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
  • Sigma Aldrich:486-84-0(sigmaaldrich)
  • MOL 文件:486-84-0.mol
  • 毒性分级:高毒
  • 哈尔满碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 146965000 哈尔满碱 Harmane 98% 500 MG 660元
  • 图谱信息:哈尔满碱(486-84-0)红外图谱(IR2) 哈尔满碱(486-84-0)红外图谱(IR1) 哈尔满碱(486-84-0)质谱(MS)
  • 急性毒性:腹腔-小鼠 LD50: 50 毫克/公斤; 皮下-兔子 LD50: 200 毫克/公斤
  • Acros Organics:Harmane, 98%(486-84-0)
  • 储运特性:库房通风低温干燥; 与食品原料分开存放
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Carbazoles 咔唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Carbazoles 咔唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Spectroscopy - Analytical Reagents
  4. Mass Spectrometry (MS) - Spectroscopy
  5. Matrix Substances for MALDI-MS - Mass Spectrometry (MS)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Imidazoline Receptor  (咪唑啉受体)

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