4-Hydroxyquinazoline 4-羟基喹唑啉

CAS 491-36-1 MFCD00511302

化学结构图

491-36-1
SMILES: O=c1[nH]cnc2ccccc12

化学属性

Mol. FormulaC8H6N2O
Mol. Weight146.149
Melting Point216-219°C
TSCANo
Appearance 本品为白色结晶，m.p.214～215℃，不溶于水。
Boiling Point303.5°C at 760 mmHg

别名和识别编码

Chemical Name4-Hydroxyquinazoline
CAS Number491-36-1
Alfabeta NameQUINAZOLINONE H43()--
MDL NumberMFCD00511302
Synonym 4(3H)-Quinazolinone {LY} 4(3H)-Quinazolinone {} {LY} 4(3H)-Quinazolinone {} {} {LY} 4(3H)-Quinazolinone {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4(3H)-Quinazolinone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number207-735-8
Beilstein Registry Number607148
PubChem Substance ID135408753
Chemical Name Translation4-羟基喹唑啉
Reaxys-RN607148
Wiswesser Line NotationT66 BVM ENJ
LabNetwork Molecule IDLN00164643
InChIInChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
Canonical SMILESO=C1NC=NC2=C1C=CC=C2
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分类

  • {SNA} Bioactive Small Molecules, Building Blocks, Chemical Synthesis, H, Heterocyclic Building Blocks, Quinazolines, 细胞生物学
  • {SNA} Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, H, Heterocyclic Building Blocks, Quinazolines
  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Quinazolines

安全信息

Warnings IRRITANT
RTECSVA2300000
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi Xi,Xn 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 609 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • 方法二:由邻氨基苯甲酸与甲酰胺环合而得。将邻氨基苯甲酸和甲胺加入不锈钢反应锅内，搅拌加热4h，油浴温度140-150℃。在搅拌下加入冷水，待温度降至60℃以下时，将产物加水搅拌均匀，放置过夜。过滤、水洗、醇洗，在100-120℃干燥，得喹唑酮，收率80%。
  • Sigma Aldrich:491-36-1(sigmaaldrich)
  • 用途二:该品是抗心律失常药常咯啉的中间体。
  • TCI Shanghai:4-羟基喹唑啉 4-Hydroxyquinazoline,>;98.0%(T)(491-36-1)
  • 海关编码:29335995
  • 4-羟基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0803 4-羟基喹唑啉 4-Hydroxyquinazoline 25G 986元 2010/06/21 121880050 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 5 GR 328元 2010/06/21 121880250 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 25 GR 1297元
  • 方法一:其制备方法是在四口烧瓶中加入邻氨基苯甲酸和甲酰胺，搅拌下加热至125～130℃，反应4h得浅红色固体，重结晶得成品。
  • 4-羟基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 H0803 4-羟基喹唑啉 4-Hydroxyquinazoline 25G 999元 2010/06/21 121880050 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 5 GR 328元 2010/06/21 121880250 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 25 GR 1297元
  • Alfa Aesar:4-羟基喹唑啉,98% 4-Hydroxyquinazoline, 98%(491-36-1)
  • 图谱信息:4-羟基喹唑啉(491-36-1)核磁图( 13 CNMR) 4-羟基喹唑啉(491-36-1)质谱(MS) 4-羟基喹唑啉(491-36-1)红外图谱(IR1) 4-羟基喹唑啉(491-36-1)红外图谱(IR2)
  • Acros Organics:4-羟基喹唑啉 4-Hydroxyquinazoline, 98%(491-36-1)
  • 敏感性:Hygroscopic
  • 上游原料:邻氨基苯甲酸 --> 2-羟基喹喔啉 --> 四口烧瓶 --> 不锈钢反应锅 --> 浅红
  • 用途一:4-(3H)喹唑啉酮是杀螨剂喹螨醚的中间体。
  • 下游产品:4-氯喹唑啉
  • MOL 文件:491-36-1.mol
  • MSDS 信息:4-Hydroxyquinazoline(491-36-1).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinoxalines 喹喔啉

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