5-Chloro-2'-deoxyuridine, 98% 5-氯-2′-脱氧尿苷

CAS 50-90-8 MFCD00006531

化学结构图

50-90-8
SMILES: O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1Cl

化学属性

Mol. FormulaC9H11ClN2O5
Mol. Weight262.649
Melting Point176-179°C
Boiling Point

别名和识别编码

Chemical Name5-Chloro-2'-deoxyuridine, 98%
CAS Number50-90-8
Synonym 5-Chloro-2'-deoxyuridine {LY} 5-Chloro-2'-deoxyuridine {} {LY} 5-Chloro-2'-deoxyuridine {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} { {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 5-Chloro-2'-deoxyuridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} 5-CHLORO-2'-DEOXYURIDINE {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} 2'-deoxy-5-chlorouridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006531
PubChem Substance ID65510
Chemical Name Translation5-氯-2′-脱氧尿苷
InChIKeyNJCXGFKPQSFZIB-RRKCRQDMSA-N
Wiswesser Line NotationT6NVMVJ EG A- ET5OTJ B1Q CQ
Beilstein Registry Number0546807
LabNetwork Molecule IDLN04679087
InChIInChI=1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
Canonical SMILESOC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1
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分类

  • Bases & Related Reagents
  • {SNA} Nucleoside Analogs, 核苷,核苷酸和寡核苷酸, 生化试剂
  • Nucleotides
  • Carbohydrates & Derivatives
  • Heterocycles
  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides

产品应用

  • A halogenated uridine derivative used in pharmaceutical compositions.

相关文献及参考

  • Brammer, K., et al.: Biochim. Biophys. Acta, 72, 217 (1963),

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P362+P364
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P317
  • P304+P340
  • P318
  • P203
  • P330 Rinse mouth. 漱口
  • P302+P352
  • P405 Store locked up. 上锁保管。
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H351 Suspected of causing cancer 怀疑致癌
RTECSYU7400000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20℃ {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADTEAS Advances in Teratology.  (New York, NY)  V.1-5, 1966-72.
   Discontinued.  Volume(issue)/page/year: 3,181,1968

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,301,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   19,563,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 umol/L
REFERENCE :
   BLFSBY Basic Life Sciences.  (Plenum Pub. Corp., 223 Spring St., New York,
   NY 10003)  V.1-    1973-  Volume(issue)/page/year: 29A,69,1984

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 91,395,1981

其他信息

  • 上游原料:氢氧化钠 --> 甲醇 --> 四氢呋喃 --> 二氯甲烷 --> 乙酐 --> 丙酮 --> 吡啶 --> 乙腈 --> 叠氮化钠 --> 乙二醇二甲醚 --> N-氯代丁二酰亚胺 --> 氯化锂 --> 硝酸铈铵 --> 2'-脱氧尿苷
  • 类别:有毒物质
  • 毒性分级:中毒
  • 储运特性:库房低温通风干燥
  • 可燃性危险特性:可燃; 火场释放有毒氮氧化物, 氯化物烟雾
  • 急性毒性:腹腔-大鼠 LD50: 2000 毫克/公斤
  • 灭火剂:水, 二氧化碳, 泡沫, 沙土
  • Sigma Aldrich:50-90-8(sigmaaldrich)
  • MOL 文件:50-90-8.mol

系列性分类


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