Pholcodine

CAS 509-67-1 MFCD00866841

化学结构图

509-67-1
SMILES: CN1CC[C@@]23[C@H]4C=C[C@H](O)[C@@H]2OC2C3=C(C[C@@H]14)C=CC=2OCCN1CCOCC1 |&1:4,5,8,10,16|

化学属性

Mol. FormulaC23H30N2O4
Mol. Weight398.55

别名和识别编码

Chemical NameMorphinan-6-alpha-ol,7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)-
CAS Number509-67-1
Synonym 3-Morpholylaethylmorphin Tetrahydro-1,4-oxazinylmethylcodeine ######## Ethnine Pholtex Morpholinylethylmorphine Hibernyl Pectolin Pholcodin Morphine, O(sup 3)-(2-morpholinoethyl)- Pholcodine Glycodine Memine Folkodin Codylin Homocodeine 3-(2-(4-Morpholinyl)ethyl)morphine Folcodine Weifacodine Dia-Tuss 7,8-Didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol Tussokon Neocodin
Wiswesser Line NotationT B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ P1 JO2-AT6N DOTJ
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分类

  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Antitussive; an opioid cough suppressant. Controlled Substance.

相关文献及参考

  • Findlay, J.W.A.: J. Clin. Pharm. Therap., 13, 5 (1988); Chen, Z.R. et al.: Br. J. Clin. Pharmacol., 26, 445 (1988); Maurer, H.H. et al.: Arzneim.-Forsch., 40, 546 (1990);

安全信息

RTECSQD1575000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 7,21,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 12,89,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 7,21,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATIO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,325,1958

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