Thio-TEPA 三亚乙基硫代磷酰胺
CAS 52-24-4 MFCD00145452
化学结构图
SMILES: S=P(N1CC1)(N1CC1)N1CC1
化学属性
| Mol. Formula | C6H12N3PS |
|---|---|
| Mol. Weight | 189.22 |
| Melting Point | 54-57 ºC |
| Solubility | 19 G/100 ML (25 ºC) |
| TSCA | No |
| Appearance | solid |
别名和识别编码
| Chemical Name | Thio-TEPA |
|---|---|
| CAS Number | 52-24-4 |
| Alfabeta Name | PHOSPHOROTHIOYLTRIAZIRIDINE 111-,,''' |
| MDL Number | MFCD00145452 |
| Synonym | 1,1,1"-phosphinothioylidynetris-aziridin 1,1’,1’’-phosphinothioylidynetris-aziridin 1,1’,1’’-phosphinothioylidynetrisaziridine Girostan N,N',N''-Tri-1,2-ethanedi N,N',N"-Triethylenethiophosphamide N,N',N″-Triethylenethiophosphoramide N,N',N''-TRIETHYLENETHIOPHOSPHORAMIDE N,N',N''-Triethylenephosphorothioic triamide Phosphorothioic acid triethylenetriamide Phosphorothioic triamid SALOR-INT L169250-1E THIO-TEPA TRIS(1-AZIRIDINYL)PHOSPHINE SULFIDE TSPA Thio-Tep Thiotepa Tiofosfamid Tiofozil Tr Tri(ethyleneimino)thiophosphoramide Triazi Tris(aziridinyl)phosphine sulfide tris-aziridin-1- {} {uni_hambur {} {} {} {} {} {} {uni_ha |
| PubChem Substance ID | 5453 |
| EC Number | 200-135-7 |
| Chemical Name Translation | 三亚乙基硫代磷酰胺 |
| Wiswesser Line Notation | T3NTJ APS&- AT3NTJ&- AT3NTJ |
| Beilstein Registry Number | 0145978 |
| LabNetwork Molecule ID | LN00158952 |
| InChI | InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Analytical Standards, Analytical/Chro
- {SNA} Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Aziridines, Chemical Structure Class, 抗生素, 生化试剂
- {SA} Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics
产品应用
- This substance is listed as a known human carcinogen. It is useful for the treatment of cancers, especially cancers resistant to chemotherapy. Antineoplastic.
相关文献及参考
- Kyriakou, C., et al.: J. Clin. Oncol., 27, 3262 (2009),
- Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/10a Year: 1985 ISBN: 3-540-07834-7 ISBN: 978-3-540-07834-0 Internet Resource: DOI:10.1007/b19984 RefComment: XXII, 634 pages. Hardcover Abstract: The volume includes an alphabetical index of all substances and a separate "ring index" with all cyclic compounds.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H350 May cause cancer 可能致癌
- H300 Fatal if swallowed 吞食致命
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S20 When using do not eat or drink 使用时，不得进食，饮水；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
- R45 May cause cancer 可能致癌
- R28 Very toxic if swallowed 吞咽极毒
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 218 mg/kg/1Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-58,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 52 mg/kg/1Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1461,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Human - man DOSE/DURATION : 33 mg/kg/3Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia REFERENCE : CMAJAX Canadian Medical Association Journal.
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg/1Y-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease REFERENCE : NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-58,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 5620 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966- Volume(issue)/page/year: 22,36,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16500 ug/kg TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen REFERENCE : FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Vol
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 2 ug REFERENCE : ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.44- 1976- Volume(issue)/page/year: 50,271,1982
TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 mg/L REFERENCE : ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94, 1930-73. For publisher information, see AMICCW. Volume(issue)/page/year: 51,9,1965
TYPE OF TEST : DNA damage TEST SYSTEM
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 ug/plate REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 250 ug/plate REFERENCE : MUREAV Mutation Resear
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intravenous TEST SYSTEM : Rodent - rat DOSE/DURATION : 1600 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,275,1979
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 52 umol/L REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 10,1580,1974
{TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 25 mg/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year: 17,405,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 2 mg/kg SEX/DURATION : male 5 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : 85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H., Springfield, IL, Charles C. Thomas, 1966 Volume(issue)/page/year: -,37,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 500 ug/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : DANND6 Dopovidi Akademii Nauk Ukrains'koi RSR, Seriya B: Geologichini, Khimichni ta Biologichni Nauki. Transactions of the Academy of Sciences of the Ukranian SSR, Series B. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) 1976- Volume(issue)/page/year: (3),59,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECI
其他信息
- 生产方法:将乙撑亚胺、三乙胺和无水苯冷却至0℃以下，搅拌下滴加硫氯化磷和苯的溶液，温度控制在5℃以下，加毕，室温下搅拌2-3h，过滤。滤饼为三乙胺盐酸盐，用无水苯洗涤。洗、滤液合并，减压蒸去苯，残液加石油醚析出结晶，冷却过滤。结晶用石油醚重结晶，得成品塞替派。收率79.4%。
- 稳定性:Stable. Incompatible with strong oxidizing agents.
- 毒害物质数据:52-24-4(Hazardous Substances Data)
- HazardClass:6.1(a)
- 用途:该品化学结构中的乙搅亚胺基能与细胞内DNA核碱基，如鸟嘌噙结合，从而使DNA变性，影响癌细胞的分裂。本品为细胞周期非特异性药物，对乳腺癌、卵巢癌有较好的疗效。对消化道腺癌、宫颈癌、甲状腺癌、肺癌和亚性黑色素瘤等也有一定疗效。
- PackingGroup:II
- MOL 文件:52-24-4.mol
- NIST化学物质信息:Thiotepa(52-24-4)
- EPA化学物质信息:Aziridine, 1,1',1''-phosphinothioylidynetris- (52-24-4)
- RTECS号:SZ2975000
- The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
京ICP备2020036287号