9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline 9,10-二甲氧基-5,8,13,13a-四氢-6H-[1,3]二氧戊环并[4,5-g]异喹啉并[3,2-a]异喹啉
CAS 522-97-4 MFCD00522974
化学结构图
SMILES: COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4
化学属性
| Mol. Weight | 339.38 |
|---|---|
| Mol. Formula | C20 H21 N O4 |
| Melting Point | >167°C (dec.) |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| CAS Number | 522-97-4 |
|---|---|
| Chemical Name | 9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline |
| Synonym | 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine Canadine |
| EC Number | 208-338-2 |
| Chemical Name Translation | 9,10-二甲氧基-5,8,13,13a-四氢-6H-[1,3]二氧戊环并[4,5-g]异喹啉并[3,2-a]异喹啉 |
| PubChem Substance ID | 34458 |
| InChI | InChI=1S/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3 |
| LabNetwork Molecule ID | LN00346571 |
| MDL Number | - |
| Canonical SMILES | - |
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分类
- Aromatics
- Heterocycles
- Neurochemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditi
相关文献及参考
- [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.
- Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010),
- Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006),
- Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009),
- [1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
- [1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
- [2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.
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