Hydroxyflutamide 羟基氟他胺
CAS 52806-53-8 MFCD00563126
化学结构图
SMILES: CC(C)(O)C(=O)NC1=CC(=C(C=C1)[N+]([O-])=O)C(F)(F)F
化学属性
| Mol. Formula | C11H11F3N2O4 |
|---|---|
| Mol. Weight | 292.21 |
别名和识别编码
| Chemical Name | Hydroxyflutamide |
|---|---|
| CAS Number | 52806-53-8 |
| Synonym | 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide 2-Hydroxyflutamide Hydroxyniphtholide Sch 16423 a,a,a-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 2-Hydroxyflutamide ?,?,?-Trifluoro-2-methyl-4'-nitro-m- Hydroxyflutamide Hydroxyniphtholide Sch 16423 a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide |
| MDL Number | MFCD00563126 |
| Chemical Name Translation | 羟基氟他胺 |
| PubChem Substance ID | 329815208 |
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分类
- {SNA} Androgen, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, H, Hormones, Schering Plough, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Androgen, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Schering Plough, Steroid Hormones
产品应用
- The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.
相关文献及参考
- Katchen, B., et al.: J. Clin. Endocrinol. Metab., 41, 373
- Joseph, J.D., et al., Inhibition of prostate cancer cell growth by second-site androgen receptor antagonists. Proc. Natl. Acad. Sci. U. S. A. , (2009)
- Ngan, S., et al., Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells. Oncogene 28 , 2051-2-63, (2009) 摘要
- Lenie, S., et al., Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis. Biol. Reprod. 80 , 685-695, (2009) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 2400 mg/kg SEX/DURATION : female 15-20 day(s) after conception TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male REFERENCE : CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 6 gm/kg SEX/DURATION : female 11-15 day(s) after conception TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male REFERENCE : CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995
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