Flufenamic acid 氟灭酸

CAS 530-78-9 MFCD00002422

化学结构图

530-78-9
SMILES: O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1

化学属性

Mol. FormulaC14H10F3NO2
Mol. Weight281.23
Melting Point132-135 °C
TSCANo
Solubility0.0265 G/L (37 ºC)
Density1.422
Appearance 淡黄色针状结晶。熔点125℃。溶于50%乙醇。
Boiling Point373.9°C at 760 mmHg
Flash Point179.9°C

别名和识别编码

Chemical NameFlufenamic acid
CAS Number530-78-9
Synonym Flufenamic acid {LY} Flufenamic acid {} {LY} Flufenamic acid {} {} {LY} Flufenamic acid {} {} {} {LY} Flufenamic acid {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00002422
EC Number208-494-1
Merck Number4132
Beilstein Registry Number1996069
PubChem Substance ID3371
Alfabeta NameTRIFLUOROMETHYLPHENYLAMINOBENZOICACID 23[]()--{}
Reaxys-RN1996069
Chemical Name Translation氟灭酸
Wiswesser Line NotationQVR BMR CXFFF
LabNetwork Molecule IDLN00179078
InChIInChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
Canonical SMILESO=C(O)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2
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分类

  • Pharmaceuticals
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, F, FA - FL, Forensic and Veterinary Standards, Neat Compounds
  • {SNA} Additional Drugs, Additional Standards, Analytical Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • Aromatics
  • Intermediates & Fine Chemicals

产品应用

  • Anti-inflammatory; analgesic.

相关文献及参考

  • Winder, et al.: Arthritis Rheum., 6, 36 (1963),
  • Inglot, et al.: J. Gen. Virol., 4, 203 (1969),
  • Zoni, et al.: Farmaco. Ed. Sci., 26, 191 (1971),

安全信息

RTECSCB4375000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Packing GroupIII
UN Number 2811 UN 2811 6.1/PG 3
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P301+P316
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 Xn
Warnings IRRITANT
Hazard Class6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,17,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2160 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 62,773,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 249 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 221,132,1976

T

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 18,845,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human
DOSE/DURATION           : 504 mg/kg/8W
REFERENCE :
   STBIBN Studia Biophysica.  (Akademie-Verlag GmbH, Postfach 1233, Berlin
   DDR-1086, Ger. Dem. Rep.) V.1-    1966-  Volume(issue)/page/year:
   50,172,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1 gm/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 38,238,1982

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 上游原料:乙醇 --> 盐酸 --> N,N-二甲基甲酰胺 --> 氢氧化钾 --> 溴乙烷 --> 铜 --> 1,4-氧氮六环 --> N,N-二甲基乙酰胺 --> 2-氯苯甲酸 --> 间氨基三氟甲苯 --> 醋酸铜 --> 2-碘苯甲酸
  • 图谱信息:氟灭酸(530-78-9)红外图谱(IR2) 氟灭酸(530-78-9)Raman光谱 氟灭酸(530-78-9)红外图谱(IR1) 氟灭酸(530-78-9)质谱(MS)
  • Alfa Aesar:氟芬那酸,97% Flufenamic acid, 97%(530-78-9)
  • 氟芬那酸:氟芬那酸是目前常用的一种非激素类的消炎镇痛药物，是氟灭酸的另一种叫法，常温下为淡黄色或淡黄绿色的结晶或结晶性粉末，味苦。几乎不溶于水，溶于乙醇。药理作用与氯丙酸相似，具有消炎、镇痛、解热作用，消炎解热作用比氨基比林、氯丙酸、阿司匹林、保泰松强，镇痛作用较差，不良反应小。临床主要用于治疗风湿性关节炎和类风湿性关节炎，对后者效果较差，偶见的胃肠道不良反应包括胃部不适、腹泻、皮疹、蛋白尿、血尿、浮肿等反应，哮喘患畜慎用。
  • 方法一:由间氨基三氟甲苯与邻氯苯甲酸缩合而得。
  • 氟灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 500G 3830元 2011/04/16 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 25G 446元 2010/06/21 165920500 氟灭酸 Flufenamic acid 97% 50 GR 707元
  • 氟灭酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 500G 2470元 2014/06/02 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 25G 288元 2010/06/21 165920500 氟灭酸 Flufenamic acid 97% 50 GR 707元
  • Acros Organics:氟芬那酸 Flufenamic acid, 97%(530-78-9)
  • MSDS 信息:Flufenamic acid(530-78-9).msds
  • 用途一:为非甾体抗炎药中间体
  • TCI Shanghai:N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid,>;98.0%(LC)(T)(530-78-9)
  • 用途二:该品为消炎镇痛药。
  • 下游产品:2-三氟甲基吩噻嗪
  • Sigma Aldrich:530-78-9(sigmaaldrich)
  • MOL 文件:530-78-9.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs & Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs & Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FA - FL - F
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic acids

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