5-(2-Chloroethyl)-4-Methylthiazole 5-(2-氯乙基)-4-甲基噻唑
CAS 533-45-9 MFCD00868012
化学结构图
SMILES: Cc1ncsc1CCCl
化学属性
| Mol. Formula | C6H8ClNS |
|---|---|
| Mol. Weight | 161.66 |
别名和识别编码
| Chemical Name | 5-(2-Chloroethyl)-4-Methylthiazole |
|---|---|
| MDL Number | MFCD00868012 |
| Chemical Name Translation | 5-(2-氯乙基)-4-甲基噻唑 |
| Synonym | WY 1485 Chlorethiazol chlormethiazole Chloro-S.C.T.Z. CHLORMETHIAZOLE HYDROCHLORIDE (5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE) Distraneurin Emineurina Clomethiazolum 氯美噻唑 CLOMETHIAZOLE 5-(2-氯乙基)-4-甲基噻唑 5-(2-Chloroethyl)-4-methylthiazole Chlorethiazole Chlormethiazol 4-Methyl-5-(beta-chloroethyl)thiazole 5-(2-Chlorethyl)-4-methylthiaziole hydrochloride Chlormethiazole ChlormethiazoleHCl Clomethiazole Somnevrin 5-(2-chloroethyl)-4-methylthiazole |
| CAS Number | 533-45-9 |
| EC Number | 208-565-7 |
| Wiswesser Line Notation | T5N CSJ D2G E1 |
| Beilstein Registry Number | 0114244 |
| LabNetwork Molecule ID | LN01264097 |
| PubChem Substance ID | 10783 |
| InChI | InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3 |
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相关文献及参考
- [2]. Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44(8):1424-30
- [1]. Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.Eur J Pharmacol. 2002 Oct 11;452(3):255-62.
- [1]. Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.Eur J Pharmacol. 2002 Oct 11;452(3):255-62.
- [2]. Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44(8):1424-30
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,167,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 8,39,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,423,1970
其他信息
- Sigma Aldrich:533-45-9(sigmaaldrich)
- 类别:有毒物质
- 毒性分级:中毒
- MOL 文件:533-45-9.mol
- 爆炸物危险特性:0
- 可燃性危险特性:可燃, 火场释放有毒氯化物, 氮氧化物, 硫氧化物烟雾
- 灭火剂:水, 二氧化碳, 泡沫, 沙土
- 储运特性:库房低温通风干燥
- 刺激数据:0
- 职业标准:0
- 急性毒性:口服-小鼠 LD50: 2110 毫克/公斤;腹腔-小鼠 LD50: 190 毫克/公斤;
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