Mexiletine hydrochloride 盐酸美西律

CAS 5370-01-4 MFCD00216024

化学结构图

5370-01-4
SMILES: Cc1cccc(C)c1OCC(C)N.Cl

化学属性

Mol. FormulaC11H18ClNO
Mol. Weight216
Melting Point200.0 to 205.0 deg-C
SolubilityDMSO 43 mg/mL Water 43 mg/mL Ethanol 43 mg/mL
Appearance powder

别名和识别编码

Chemical NameMexiletine hydrochloride
CAS Number5370-01-4
Synonym 1-(2,6-DIMETHYLPHENOXY)-2-PROPANAMIDE HYDROCHLORIDE 1-(2,6-DIMETHYLPHENOXY)-2-PROPANAMINE HYDROCHLORIDE 1-(2,6-DIMETHYLPHENOXY)-2-PROPANANMINE HYDROCHLORIDE 1-(2,6-Dimethylphenoxy)-2-aminopropane hydrochloride 1-(2,6-Dimethylphenoxy)-2-propanamine Hydrochloride 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride 1-(2,6-XYLYLOXY)-2-AMINOPROPANE HYDROCHLORIDE SALT 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride 1-(2,6-dimethylphenoxy)-2-aminopropanehydrochloride 1-(2,6-dimethylphenoxy)-2-propanaminhydrochloride 1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐 1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride 1-(2,6-二甲基苯氧基)-2-丙胺盐酸盐 1-Methyl-2-(2,6-xyloxy)ethylamine hydrochloride 1-Methyl-2-(2,6-xylyloxy)-ethylamine hydrochloride 1-Methyl-2-(2,6-xylyloxy)ethylamine Hydrochloride KO
MDL NumberMFCD00216024
PubChem Substance ID21467
EC Number250-825-7
Chemical Name Translation盐酸美西律
Merck Number6169
Reaxys-RN4209895
Wiswesser Line NotationZY1&1OR B1 F1 &GH
LabNetwork Molecule IDLN00220304
InChIInChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Boehringer Ingelheim, Cell Signaling and Neuroscience, Ion Channels, M, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, Voltage-gated Ion Channels, 细胞生物学
  • {SNA} Approved Therapeutics/Drug Candidates,
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphab
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Boehringer Ingelheim, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, M, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, Voltage-gated Ion Channels

产品应用

  • Antiarrhythmic (class IB).

相关文献及参考

  • Singh, E.M., et al.: Br. J. Pharmacol., 44, 1 (1972),
  • Scott, K.N., et al.: Drug Metab. Dispos., 1, 506 (1973),
  • Chew, C.Y.C., et al.: Drugs, 17, 161 (1979),

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 储存温度-20°C 2-8°C
RTECSKR9310000
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Musculoskeletal - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,922,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Musculoskeletal - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,922,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 13,922,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 356 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  St

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reprod

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 27500 ug/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 14,550,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 14,550,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 14,550,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : O

其他信息

  • 用途一:抗心律失常药
  • color:white
  • Sigma Aldrich:5370-01-4(sigmaaldrich)
  • 盐酸美西律价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M2040 盐酸美西律 Mexiletine Hydrochloride 5G 957元 2014/06/02 M2040 盐酸美西律 Mexiletine Hydrochloride 1G 319元
  • MOL 文件:5370-01-4.mol

系列性分类

  1. Life Science 生命科学
  2. Antibodies (Primary & Secondary) 抗体
  3. Clone Index - Antibodies
  4. 2C-2E - Clone Index
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. M - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amine Salts - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amine Salts - Nitrogen Compounds
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Other Sodium Channel Modulators - Sodium Channel Modulators

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