Scopolamine Hydrochloride 盐酸东莨菪碱

CAS 55-16-3 MFCD00058096

化学结构图

55-16-3
SMILES: Cl.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]1O[C@@H]12)OC(=O)[C@@H](CO)C1C=CC=CC=1 |&1:3,5,7,8,10,14|

化学属性

Mol. FormulaC17H21NO4.ClH
Mol. Weight339.85
Flash Point77 °C
SolubilitySoluble in water: 50 mg/mL
Appearance powder

别名和识别编码

Chemical NameScopolamine Hydrochloride
CAS Number55-16-3
MDL NumberMFCD00058096
Synonym Scopolamine, hydrochloride 5-alpha-h-tropan-3-alpha-ol,6-beta,7-beta-epoxy-1-alpha-(-)-tropate(est 莨菪碱 天仙子碱 盐酸盐 莨菪胺 ScopolamineSeries (-)-盐酸东莨菪碱 Hyoscine hydrochloride (-)-莨菪胺 盐酸盐 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, 6-beta,7-beta-epoxy-, (-)-tropate HYOSCINE HYDROCHLORIDE )-Scopolamine hydrochloride chlorhydratedescopolamine SCOPINE TROPATE HYDROCHLORIDE Scopine tropate (-)-东莨菪碱盐酸盐; 天仙子碱盐酸盐; 莨菪胺 (-)-SCOPOLAMINE HYDROCHLORIDE (- (-)-Scopolaminhydrochlorid 0(sup2,4))non-7-ylester,hydrochloride,(7(s)-(1-alpha,2-beta,4-beta,5-alpha er),hcl, SCOPINE TROPATE Chlorhydrate de scopolamine HYPACONITINE(P) (-)-东莨菪碱 盐酸盐 Hyoscine hydrochloride, Scopine tropate SCOPOLAMINE HYDROCHLORIDE 盐酸(-)-莨菪胺
Beilstein Registry Number4168778
EC Number200-225-6
PubChem Substance ID24899457
Chemical Name Translation盐酸东莨菪碱
Wiswesser Line NotationT C356 A AN DOTJ A1 HOVYR&1Q &GH
LabNetwork Molecule IDLN02126871
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分类

  • Analytical Standards, Analytical/Chromatography, Biotoxins, Chromatography, Life Sciences Standards, Phytotoxins
  • {SNA} Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Neuroscience, Neurotransmission, Neurotransmitters, S
  • {SNA} Alkaloids / Nitrogen Containing Compounds, Analytical Standards, Biotoxin and Mycotoxin Standards, Food and Cosmetic Component Standards, Phytochemical Standards, Phytotoxins, 分析/色谱

产品应用

  • 竞争性非选择性蕈毒性乙酰胆碱拮抗剂。常在实验动物上进行莨菪碱诱导健忘症实验。

相关文献及参考

  • Merck: 14,8406
  • Rush, D.K., Scopolamine amnesia of passive avoidance: a deficit of information acquisition. Behav. Neural Biol 50 , 255-274, (1988)

安全信息

RTECSCY1634501
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
  • H300+H310+H330
WGK Germany3
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T+
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S25 Avoid contact with eyes 避免眼睛接触；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
UN Number 1544 UN 1544 6.1/PG 3
Storage condition 储存温度-20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 88,713,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 104 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year: 29,39,1972

其他信息

  • 急救治疗:发现中毒症状状，催吐或吞入活性炭，必要时送医院诊治。
  • 类别:有毒物质
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • 毒性分级:中毒
  • 注意事项:[1]按亩用剂量量取药液，兑水50g充分搅拌，均匀喷雾。 [2]本品不易与其它农药混配使用。 [3]本品应存放于阴凉干燥处，防止曝晒。 [4]若误服或出现中毒症状，送医院诊治
  • 用途一:竞争性非选择性蕈毒性乙酰胆碱拮抗剂。常在实验动物上进行莨菪碱诱导健忘症实验。
  • MOL 文件:55-16-3.mol
  • Sigma Aldrich:55-16-3(sigmaaldrich)
  • color:white
  • 急性毒性:口服-小鼠 LD50: 1275 毫克/公斤; 腹腔-小鼠 LD50: 104 毫克/公斤
  • F:3-8
  • 储运特性:库房低温, 通风, 干燥
  • (-)-Scopolamine hydrochloride is a competitive nonselective mAChR M antagonist. This compound blocks the binding of the acetylcholine ligand and prevents the opening of ion channels.
  • 可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物, 氯化物气体

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. S - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Biotoxins - Life Sciences Standards
  6. Phytotoxins - Biotoxins

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