Isopromethazine hydrochloride N,N-二甲基-2-(10H-吩噻嗪-10-基)丙烷-1-胺盐酸盐 (异丙嗪杂质)

CAS 5568-90-1 MFCD05568901

化学结构图

5568-90-1
SMILES: CC(CN(C)C)N1c2ccccc2Sc2ccccc21.Cl

化学属性

Mol. Weight320.88
Mol. FormulaC17H21ClN2S
Melting Point204 °C

别名和识别编码

CAS Number5568-90-1
Chemical NameIsopromethazine hydrochloride
Synonym N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {} {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {} {} {} {} {LY} N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride (Promethazine Impurity) {} {} {} {} {} {} {} {} {LY} N,N
Chemical Name TranslationN,N-二甲基-2-(10H-吩噻嗪-10-基)丙烷-1-胺盐酸盐 (异丙嗪杂质)
Wiswesser Line NotationT C666 BN ISJ BY1&1N1&1 &GH
PubChem Substance ID110668
InChIInChI=1S/C17H20N2S.ClH/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
Canonical SMILESCC(CN(C)C)N1C2=C(C=CC=C2)SC3=C1C=CC=C3.Cl
MDL NumberMFCD01706895
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分类

  • Heterocycles
  • Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds,

产品应用

  • Promethazine (P757000) impurity.

相关文献及参考

  • Gasco, M.R., et al.: J. Pharma. Sci., 68, 612 (1979),

安全信息

RTECSSO5500000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Blood - hemorrhage
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 90,224,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 95,428,1953

Hazard statements
  • H302 Harmful if swallowed 吞食有害
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store

系列性分类


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