6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purin-2-amine 硫咪嘌呤
CAS 5581-52-2 MFCD00049228
化学结构图
SMILES: Cn1cnc([N+](=O)[O-])c1Sc1nc(N)nc2nc[nH]c12
化学属性
| Mol. Formula | C9H8N8O2S |
|---|---|
| Mol. Weight | 292.31 |
别名和识别编码
| Chemical Name | 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purin-2-amine |
|---|---|
| CAS Number | 5581-52-2 |
| Synonym | ######## Tiamiprine 2-Amino-6-(1'-methyl-4'-nitro-5'-imidazolyl)mercaptopurine Thiamiprine 6-Benzylaminopurine BW 57-323 2-Amino-6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine NSC-38887 Guaneran ITG BW 57-323H 1-Methyl-4-nitro-5-(2'-amino-6'-purinyl)mercaptoimidazide 1H-Purin-2-amine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)-thio)- |
| Chemical Name Translation | 硫咪嘌呤 |
| Wiswesser Line Notation | T56 BN DM FN HNJ GZ IS- DT5N CNJ C1 ENW |
| Beilstein Registry Number | 1164867 |
| PubChem Substance ID | 3379405 |
| InChI | InChI=1S/C9H8N8O2S/c1-16-3-13-6(17(18)19)8(16)20-7-4-5(12-2-11-4)14-9(10)15-7/h2-3H,1H3,(H3,10,11,12,14,15) |
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分类
- Heterocycles
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- An immunosuppressant. Antiarthritic.
相关文献及参考
- Chalmers, A.H. et al.: Biochem. Pharmacol., 21, 2662 (1972); Krenitsky, T.A. et al.: J. Med. Chem., 32, 1471 (1989);
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 34,284,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 136 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 34,284,1971
{haz{hazard_comTYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 5 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,291,1962
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 5040 mg/kg SEX/DURATION : m
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE : 15 mg/kg SEX/DURATION : female 12-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TNEOAO Transactions of the New England Obstetrical and Gynecological Society. Volume(issue)/page/year: 18,57,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE : 15 mg/kg SEX/DURATION : female 4-6 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : TNEOAO Transactions of the New England Obstetrical and Gynecological Society. Volume(issue)/page/year: 18,57,1964
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