N-Acetyl Dapsone N-乙酰氨苯砜
CAS 565-20-8 MFCD00672496
化学结构图
SMILES: CC(=O)Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1
化学属性
| Mol. Formula | C14H14N2O3S |
|---|---|
| Mol. Weight | 290.34 |
| Melting Point | 238-240 °C |
别名和识别编码
| Chemical Name | N-Acetyl Dapsone |
|---|---|
| MDL Number | MFCD00672496 |
| CAS Number | 565-20-8 |
| Synonym | 4'-Sulfanilylacetanilide Acetamide, N-(4-((4-aminophenyl)sulfonyl)phenyl)- MADDS N-Acetyl Dapsone N-Acetyl dapsone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| Chemical Name Translation | N-乙酰氨苯砜 |
| Wiswesser Line Notation | ZR DSWR DMV1 |
| Beilstein Registry Number | 2746651 |
| LabNetwork Molecule ID | LN01283254 |
| PubChem Substance ID | 11257 |
| InChI | InChI=1S/C14H14N2O3S/c1-10(17)16-12-4-8-14(9-5-12)20(18,19)13-6-2-11(15)3-7-13/h2-9H,15H2,1H3,(H,16,17) |
| Canonical SMILES | CC(NC1=CC=C(S(=O)(C2=CC=C(N)C=C2)=O)C=C1)=O |
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分类
- {SNA} Drug and Xenobiotic Metabolism, M, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, M, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors
- Sulfur & Selenium Compounds
- Pharmaceuticals
- {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, M, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, 细胞生物学
- Intermediates & Fine Chemicals
- {SNA} Bioactive Small Molecule Alphabetical Index, Drug and Xenobiotic Metabolism, M,
- {S
产品应用
- A metabolite of Dapsone (D193250).
相关文献及参考
- Shin, I., et al.: J. App. Pharmacol., 10, 193 (2002),
- Bhaiya, P., et al.: Toxicol. App. Pharmacol., 215, 158 (2006),
安全信息
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H318 Causes serious eye damage 严重伤害眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 6,251,1951
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