U-46619 9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素
CAS 56985-40-1 MFCD00135238
化学结构图
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H]2C[C@H]1OC2
化学属性
| Mol. Formula | C21H34O4 |
|---|---|
| Mol. Weight | 350.49 |
别名和识别编码
| Chemical Name | F2α U 46619 |
|---|---|
| Synonym | 9a,11a-Methanoepoxy-15-hydroxyprosta-5,13-dienoic acid 9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α U 46619 U-46619 U46619 |
| CAS Number | 56985-40-1 |
| PubChem Substance ID | 24894197 |
| Beilstein Registry Number | 4267334 |
| MDL Number | MFCD00135238 |
| Chemical Name Translation | 9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 |
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分类
- Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D-DIF, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids, Lipids in Cell Signaling, Prostaglandins
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, D-DIF, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids in Cell Signaling, Prostaglandins, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,
相关文献及参考
- [2]. Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313.
- [3]. Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73.
- Kampf, G., and Ritter J.M., Time-dependent inhibition by glyceryl trinitrate of platelet aggregation caused by U46619 (a thromboxane/endoperoxide receptor agonist). Br. J. Clin. Pharmacol. 38 , 80-82, (1994) 摘要
- [1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit pla
- [1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104.
安全信息
GHS Symbol
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H319 Causes serious eye irritation 严重刺激眼睛
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P304+P340+P312
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P337+P313
- P403+P235
- R11 Highly flammable 非常易燃
- R36 Irritating to eyes 刺激眼睛
- R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 66 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 224,369,1983
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