1-[4-(2-Methoxyphenyl)Piperazin-1-yl]-3-Naphthalen-1-Yloxypropan-2-ol;Dihydrochloride 盐酸萘哌地尔

CAS 57149-08-3 MFCD00153845

化学结构图

57149-08-3
SMILES: COC1C=CC=CC=1N1CCN(CC(O)COC2C=CC=C3C=CC=CC3=2)CC1

化学属性

Mol. Weight392.50
Mol. FormulaC24H28N2O3
Melting Point125.0 to 129.0 deg-C

别名和识别编码

CAS Number57149-08-3
Chemical Name1-[4-(2-Methoxyphenyl)Piperazin-1-yl]-3-Naphthalen-1-Yloxypropan-2-ol;Dihydrochloride
Synonym rac-4-(2-Methoxyphenyl)-?-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride Avishot Flivas KT 611
Chemical Name Translation盐酸萘哌地尔
Reaxys-RN629965
Beilstein Registry Number23(5)2,135
MDL NumberMFCD00242741
PubChem Substance ID87560652
Merck Number6356
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A ?-1-Adrenergic receptor antagonist, antihypertensive.

相关文献及参考

  • [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.
  • Farthing, M.J.G., et al.: Postgrad. Med. J., 70, 363 (1994),
  • Kirsten, et al.: Eur. J. Clin. Pharmacol., 46, 271 (1994),
  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
  • [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
  • [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by alterin

安全信息

RTECSTL9336500

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

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