7-Ethoxy-3H-Phenoxazin-3-One 7-乙氧基-3H-吩噁嗪-3-酮

CAS 5725-91-7 MFCD00037661

化学结构图

5725-91-7
SMILES: CCOc1ccc2nc3ccc(=O)cc-3oc2c1

化学属性

Mol. FormulaC14H11NO3
Mol. Weight241.24
Melting Point223-225°C
TSCANo
SolubilitySoluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water.
Boiling Point
Flash Point-

别名和识别编码

Chemical Name7-Ethoxy-3H-Phenoxazin-3-One
CAS Number5725-91-7
Synonym 7-Ethoxyresorufin {LY} 7-Ethoxyresorufin {} {LY} 7-Ethoxyresorufin {} {} {LY} 7-Ethoxyresorufin {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin
MDL NumberMFCD00037661
PubChem Substance ID3294
Beilstein Registry Number225973
Chemical Name Translation7-乙氧基-3H-吩噁嗪-3-酮
InChIKeyCRCWUBLTFGOMDD-UHFFFAOYSA-N
LabNetwork Molecule IDLN01293567
InChIInChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3
Canonical SMILESO=C1C=CC2=NC3=C(C=C(OCC)C=C3)OC2=C1
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分类

  • {SNA} Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Flow Cytometry, Fluorescent Enzyme Substrates for Spectroscopy, Fluorescent Probes, Labels, Particles and Stains, Luminescent Compounds/Detection, R, Wavelength Index
  • {SNA} Alphabetical, Biochemicals and Reagents, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Flow Cytometry, Fluorescent Enzyme Substrates for Spectroscopy, Fluorescent Probes, Labels, Particles and Stains, Luminescent Compounds/Detection, R, Wavelength Index, 生物活性小分子,
  • {SNA} Alphabetical,

产品应用

  • 7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

相关文献及参考

  • [2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.
  • Donato, M.T., et al.: Anal. Biochem., 213, 29 (1993),
  • [1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.
  • [1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.
  • [2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
Storage condition -20°C {LY} -20°C 4 4°C 4°C, Inert atmosphere 4℃ {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
GHS Symbol

其他信息

  • 7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.
  • Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Detection - Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Indicators and Probes - Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. R - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Enzyme Substrates - Fluorescent Probes, Labels, Particles and Stains
  5. Alphabetical - Fluorescent Enzyme Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Enzyme Substrates - Fluorescent Probes, Labels, Particles and Stains
  5. Alphabetical - Fluorescent Enzyme Substrates
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Enzyme Substrates - Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Enzyme Substrates for Flow Cytometry - Fluorescent Enzyme Substrates
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FA - FL - F
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Substrates - Enzymes, Inhibitors, and Substrates
  5. Substrates by Enzyme - Enzyme Substrates
  6. Cytochrome P450 - Substrates by Enzyme
  1. Medical Research Areas
  2. Metabolism
  3. Cytochrome P450  (细胞色素P450)

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