1-(Bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride 1-(双(4-氯苯基)甲基)-3-(2-((2,4-二氯苄基)氧基)-2-(2,4-二氯苯基)乙基)-1H-咪唑-3-鎓氯化物

CAS 57265-65-3 MFCD00077679

化学结构图

57265-65-3
SMILES: [Cl-].ClC1=CC(Cl)=CC=C1COC(C[N+]1=CN(C=C1)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1Cl

化学属性

Mol. FormulaC31H23Cl7N2O
Mol. Weight688

别名和识别编码

Chemical Name1-(Bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride
Synonym 1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride R 24571 钙调蛋白抑制剂 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride 1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride R 24571
MDL NumberMFCD00077679
PubChem Substance ID24278023
Beilstein Registry Number6470244
CAS Number57265-65-3
Chemical Name Translation1-(双(4-氯苯基)甲基)-3-(2-((2,4-二氯苄基)氧基)-2-(2,4-二氯苯基)乙基)-1H-咪唑-3-鎓氯化物
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分类

  • {SNA} A to C, Calcium Antagonists, Calmodulin-regulated enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Intracellular Calcium Signaling, PI3K-Akt-mTOR Enzyme Regulators, 生化试剂, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 肿瘤生长调节, 酶、抑制剂和底物
  • {SNA} A to C, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Calcium Antagonists, Calmodulin-regulated enzymes, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates,

相关文献及参考

  • 1. Sunagawa, M., et al., Direct block of Ca 2+ channels by calmidazolium in cultured vascular smooth muscle cells J. Cardiovasc. Pharmacol. 34 , 488-494, (1999) 摘要
  • Fischer, T.H., et al., An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium. Biochemistry 26 , 8024-8030, (1987) 摘要
  • Ichikawa, M., et al., Anticalmodulin drugs block the sodium gating current of squid giant axons. J. Membr. Biol. 120 , 211-222, (1991) 摘要
  • Tatsumi, R., et al., A Role For Calcium-calmodulin In Regulating Nitric Oxide Production During Skeletal Muscle Satellite Cell Activation. Am. J. Physiol. Cell Physiol. 296 , C922-9, (2009) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics A-F - Antibiotics A to Z
  1. Life Science 生命科学
  2. Cancer Research
  3. Tumor Growth Regulation - Cancer Research
  4. PI3K-Akt-mTOR Enzyme Regulators - Tumor Growth Regulation
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Calcium Antagonists - Intracellular Calcium Signaling
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Calmodulin-regulated enzymes - A to C
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Other - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Intracellular Calcium Signaling
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Arachidonate 12-Lipoxygenase

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