Methyl (E)-3-(3-(N-((4'-(Dimethylamino)-[1,1'-Biphenyl]-4-Yl)Methyl)Cyclohexanecarboxamido)Phenyl)Acrylate (E)-3-(3-(N-((4’-(二甲基氨基)-[1,1’-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯

CAS 574013-66-4 MFCD09971007

化学结构图

574013-66-4
SMILES: CN(C)C1C=CC(=CC=1)C1=CC=C(CN(C2=CC(/C=C/C(=O)OC)=CC=C2)C(=O)C2CCCCC2)C=C1

化学属性

Mol. FormulaC32H36N2O3
Mol. Weight496.647

别名和识别编码

Chemical NameMethyl (E)-3-(3-(N-((4'-(Dimethylamino)-[1,1'-Biphenyl]-4-Yl)Methyl)Cyclohexanecarboxamido)Phenyl)Acrylate
Chemical Name Translation(E)-3-(3-(N-((4’-(二甲基氨基)-[1,1’-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯
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相关文献及参考

  • [2]. Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92.
  • [3]. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65.
  • [1]. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7.
  • [1]. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7.
  • [2]. Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92.
  • [3]. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. FXR  (法尼酯X受体)

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