R112 3,3'-((5-氟-2,4-嘧啶二基)二亚胺)二苯酚

CAS 575474-82-7 MFCD75474827

化学结构图

575474-82-7
SMILES: Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1

化学属性

Mol. Weight312.3
Appearance White to off white solid powder
SolubilitySoluble in DMSO, not soluble in water.

别名和识别编码

Chemical Name Translation3,3'-((5-氟-2,4-嘧啶二基)二亚胺)二苯酚
Chemical NameR112
FormulaC16H13FN4O2
Synonym R112; R112; R 112.
IUPAC Name3,3'-((5-fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
InChIKeyTVKGTSHBQZEFEE-UHFFFAOYSA-N
InChIInChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
Canonical SMILESFC1=CN=C(NC2=CC(O)=CC=C2)N=C1NC3=CC(O)=CC=C3
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品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L).

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Syk

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