• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams), Spectrum of Activity, 抗生素, 生化试剂
• {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Biochemicals and Reagents, Chemical Structure Class,
• {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechani

产品应用

• A first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and n

相关文献及参考

• Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 89 mg/kg/19D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   AACHAX Antimicr

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 955 mg/kg/22D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   AACHAX Antimicrobial Agents and Chemotherapy (1961-70).  (Ann Arbor, MI)
   1961-70.  For publisher information, see AMACCQ.  Volume(issue)/page/year:
   -,272,1963

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIDIAQ Journal of Infectious Diseases.  (Univ. of Chicago Press, Journals
   Div., POB 37005, Chicago, IL 60637)  V.1-    1904- Volume(issue)/page/year:
   137,S51,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5670 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 27,746,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on sei

其他信息

• 下游产品:头孢呋肟
• 储运特性:库房低温, 通风, 干燥
• 可燃性危险特性:可燃, 火场排出氮氧化物, 硫氧化物和氧化钠辛辣刺激烟雾
• 上游原料:醋酸钠 --> 乙酸丁酯 --> 7-氨基头孢烷酸 --> 噻吩乙酰氯
• MOL 文件:58-71-9.mol
• 毒性分级:低毒
• 急性毒性:口服- 大鼠 LD50: >;10000 毫克/ 公斤; 口服- 小鼠 LD: >; 10000 毫克/公斤
• MSDS 信息:58-71-9.msds
• 类别:有毒物品
• 方法一:以发酵生产的头孢菌素C为原料，经保护性水解得7-氨基头孢烷酸（7-ACA），与噻吩乙酰氯缩合，所得产物经乙酸丁酯提取，活性炭脱色，最后加入甲醇醋酸钠成盐，结晶而得头孢噻吩钠。
• Sigma Aldrich:58-71-9(sigmaaldrich)
• 灭火剂:水, 二氧化碳, 干粉, 砂土
• 用途二:广谱繁殖期杀菌型抗生素，对青霉素酶稳定，抗革兰阳性菌作用很强
• 用途三:该品为广谱繁殖期杀菌型抗生素。主要用于耐青霉素G的细菌引起的感染，如呼吸系统、胆道、泌尿道感染、金葡菌性脑膜炎、心内膜炎、败血症、扁桃体炎，骨髓炎和猩红热等。
• 用途一:广谱繁殖期杀菌型抗生素，对青霉素酶稳定，抗革兰氏阳性菌作用很强