Meptazinol Hydrochloride 3-(3-乙基六氢-1-甲基-1H-氮杂卓-3-基)苯酚盐酸盐

CAS 59263-76-2 MFCD00941476

化学结构图

59263-76-2
SMILES: Cl.CCC1(CN(C)CCCC1)C1C=C(O)C=CC=1

化学属性

Mol. FormulaC15H23NO· HCl
Mol. Weight269.81

别名和识别编码

Chemical NameMeptazinol Hydrochloride
CAS Number59263-76-2
Synonym 1-Methyl-3-ethyl-3-(m-hydroxy-phenyl)hexahydro-1H-azepine 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol hydrochloride 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride IL-22811 hydrochloride WY-22811 hydrochloride IL-22811 hydrochloride Meptazinol hydrochloride Phenol, m-(3-ethyl-1-methyl-hexahydro-1H-azepin-3-yl)-, hydrochloride WY-22811 hydrochloride m-(3-Ethyl-1-methyl-hexahydro-1H-azepin-3-yl)phenol hydrochloride
MDL NumberMFCD00941476
EC Number261-683-0
Wiswesser Line NotationT7NTJ A1 C2 CR CQ &GH
Chemical Name Translation3-(3-乙基六氢-1-甲基-1H-氮杂卓-3-基)苯酚盐酸盐
LabNetwork Molecule IDLN01288220
PubChem Substance ID329817952
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分类

  • Pharmaceuticals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, M, Wyeth
  • Intermediates & Fine Chemicals,
  • {SNA} Analytical and Industrial Enzymes, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinesterase Inhibitors, Cholinesterase and Organophosphate Detection Reagents,

产品应用

  • Mixed opioid agonist-antagonist. Analgesic (narcotic).

相关文献及参考

  • Davies, G., et al.: Eur. J. Clin. Pharmacol., 23, 535 (1982),
  • Johnson, Holmes, B., et al.: Drugs, 30, 285 (1985),
  • R.E., et al.: Clin. Pharmacol. Ther., 41, 426 (1987),

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany1
Signal word Warning
RTECSSL4250000
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 282 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 9,73,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 9,73,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 9,73,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 9,73,1978

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Wyeth - Approved Therapeutics/Drug Candidates

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