Levomethadone hydrochloride

CAS 5967-73-7 MFCD N/A

化学结构图

5967-73-7
SMILES: CCC(=O)C(C[C@@H](C)[NH+](C)C)(c1ccccc1)c1ccccc1.[Cl-]

化学属性

Mol. Weight345.95
Mol. FormulaC21H27NO.ClH

别名和识别编码

CAS Number5967-73-7
Chemical NameLevomethadone hydrochloride
Synonym l-Methadone hydrochloride Levothyl Hydrochlor L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride Levomethadone Hydrochloride (-)-Methadone Hydrochloride l-Amidone hydrochloride l-Dolophine hydrochloride 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (R)- l-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride Levomethadone hydrochloride (6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride (-)-Methadone hydrochloride 1,1-Diphenyl-1-(2-dimethylaminopropyl)-2-butanone l-Polamidon hydrochloride
PubChem Substance ID22266
InChIInChI=1S/C21H27NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17H,5,16H2,1-4H3;1H/t17-;/m1./s1
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分类

  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A component of pharmaceuticals used in the treatment of opioid dependence.

相关文献及参考

  • Shiran, M., et al.: Brit. J. Clin. Pharmacol., 67, 29 (2008),
  • Esteban, J., et al.: Drug Metab. Lett., 2, 269 (2008),

安全信息

RTECSMJ6475000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 97300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOCEAH Journal of Organic Chemistry.  (American Chemical Soc., Distribution
   Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)  V.1-
   1936-  Volume(issue)/page/year: 17,321,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6483 ug/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 145,11,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   APACAB Acta Physiologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-60, 1950-82.  Volume(issue)/page/year: 4,363,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 44 ug/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - analgesia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,282,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EX

Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P301+P316
  • P304+P340
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

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