N-亚硝基双(2-羰基丙基)胺 N-亚硝基双(2-羰基丙基)胺

CAS 60599-38-4 MFCD00126918

化学结构图

60599-38-4
SMILES: CC(=O)CN(CC(C)=O)N=O

化学属性

Mol. FormulaC6H10N2O3
Mol. Weight158.16

别名和识别编码

Chemical NameN-nitrosobis(2-oxopropyl)amine
CAS Number60599-38-4
Synonym 1,1'-(Nitrosoimino)bis-2-propanone 2,2'-Dioxo-di-n-propylnitrosamine 2,2'-Dioxopropyl-N-propylnitrosamine 2,2?-Dioxo-N-nitroso-dipropylamine 2-Propanone, 1,1'-(nitrosoimino)bis- Acetone, (nitrosoimino)di- BOP Bis-(2-oxopropyl)-N-nitrosamine Di-oxo-di-n-propylnitrosamine N,N-Di(2-oxopropyl)nitrosamine N-Nitroso-N,N-di(2-oxypropyl)amine N-Nitrosobis(2-oxopropyl)amine N-nitrosobis(2-oxopropyl)amine
MDL NumberMFCD00126918
Chemical Name TranslationN-亚硝基双(2-羰基丙基)胺
Wiswesser Line Notation1V1NNO&1V1
Beilstein Registry Number2245698
PubChem Substance ID329785233
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分类

  • Mutagenesis Research Chemicals
  • Nicotine Derivatives
  • {SNA} Amines, Building Blocks, C6, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • N-Nitrosobis(2-oxopropyl)amine is a potent and selective pancreatic carcinogen in the Syrian golden hamster. This model has been used to study pancreatic cancer as chemically induced pancreatic neopl

相关文献及参考

  • Onishi, M., et al.: J. Toxicol. Pathol., 20, 263 (2007),
  • Morales Helguera, A., et al.: Chem. Res. Toxicol., 21, 633 (2008),
  • Shimizu, K., et al.: Mol. Carcinogen., 47, 80 (2008),

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES O

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 40 mg/kg
                          female 8-14 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Endocrine - thyroid tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,3663,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Endocrine - thyroid tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 79,698,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : S

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - ra

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,13,1978

RTECSJL9678000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   2,323,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 205 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,31,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 89 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Liver - other changes
   Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   58

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,13,1978

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   48,59,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 144,197,1985

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 30 mg/kg
REFERENCE :
   PNASA6 Proceed

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 7

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 13,223,1992

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   CRTOEC Chemical Research in Toxicology.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC
   20037)  V.1-    1988-  Volume(issue)/page/year: 3,150,1990

TYPE OF TEST

WGK Germany3

系列性分类

  1. C6 - Amines

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