Amitrol 3-氨基-1,2,4-三氮唑

CAS 61-82-5 MFCD00005230

化学结构图

61-82-5
SMILES: Nc1ncn[nH]1

化学属性

Mol. FormulaC2H4N4
Mol. Weight84
Melting Point147-156
Density1.138
TSCAYes
Solubility280 g/L (20 °C)

别名和识别编码

Chemical NameAmitrol
Synonym 1, 1,2,4-TRIAZOL-3-AMINE 1H-1,2,4-TRIAZOL-3-YLAMINE 1H-1,2,4-Triazol-3-ylamine 3,A-T 3-Amino-1,2, 3-Amino-1,2,4-triazole 3-Amino-1H-1,2,4-triazole 3-Amino-s-triazole 3-Aminotriazole 3-氨基 3-氮基-1,2,4-三氮唑 AKOS MSC-0735 AMITROLE AT AURORA KA-678 AZOLAN Amerol Aminotriazole Amitril T.L. Amitrol 90 Amitrole Amizol DP NAU Azaplant kombi Domatol Domatol 88 ENT 25445 Emisol Rado Solution concentree T271 Weedar AT Weedazol amino-1,2,4-triazole amitrole (ISO) {} {} {} {Chemi {} {} {} {Chemica {} {} {} {hazard_co {}
MDL NumberMFCD00005230
PubChem Substance ID1639
Beilstein Registry Number107687
CAS Number61-82-5
EC Number200-521-5
Merck Number489
Chemical Name Translation3-氨基-1,2,4-三氮唑
Reaxys-RN107687
Wiswesser Line NotationT5MN DNJ CZ
LabNetwork Molecule IDLN00193917
InChIInChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)
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分类

  • {SNA} A to C, Catalase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, 生化试剂, 酶、抑制剂和底物
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 5ring; 1fragment
  • {SNA} 2000/60
  • {SNA} 2000/60/EC, A-B, Additional Standards, Analytical Standards, European Community: ISO, DIN and DL 152, Food and Cosmetic Component Standards, Method and Regulation Specific, Pesticides, Bactericides, Fungicides and Disinfectants, Standards for Personal Care and Cosmetic Products, Triazoles, neats, prohibited substances (EU-REGULATION No 1223/2009), 农残和代谢标准品, 分析/色谱, 按照字母排序, 灭草剂
  • {SNA} 2000/60/EC, A, A-B,

产品应用

  • 可作医药中间体,用于合成药物唑嘧胺,唑嘧胺（乐可安）的中间体，曲匹地尔，亦用作除草剂（非选择性）及用于蛋白质中色氨酸的测定。

相关文献及参考

  • Short: IV/8A
  • Short: EINECS
  • Merck: 14,489
  • Merck 14 ,489
  • Merck: 14,489 Beilstein:26(3/4)1073

安全信息

RTECSXZ3850000
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P312+P330
  • P302+P350
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P333+P313
  • P337+P313
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Hazard Codes 9
WGK Germany2
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Signal word Warning
Safety Statements
  • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Packing GroupIII
UN Number 3077 UN 3077 9/PG 3 UN3077
Risk Statements
  • R48/22
  • R51/53
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Storage condition -20°C
Hazard Class9 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 gm/kg/60W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   NMJOAA Nagoya Medical Journal.  (Nagoya City Univ. Medical School, Kawasumi,
   Mizuho-cho, Mizuho-ku, Nagoya 467, Japan)  V.1-    1953-
   Volume(issue)/page/year: 23,83,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4595 mg/kg/2.5Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
   Endocrine - thyroid tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   69,161,1983

TYP

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 gm/kg/3W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,1101,1969

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3670 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/yea

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,33,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   10,97,1965

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 250 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- V

TYPE OF TES

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 57,277,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,351,1981

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 600 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 147,288,1985

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 80 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2600 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   33,41,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 ug/kg
SEX/DURATION            : female 22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 145,284,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4176 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1935 mg/kg
SEX/DURATION            : fema

其他信息

  • 可燃性危险特性:燃烧产生有毒氮氧化物气体
  • 毒性分级:中毒
  • MOL 文件:61-82-5.mol
  • 3-氨基-1,2,4-三氮唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0432 3-氨基-1,2,4-三唑 3-Amino-1,2,4-triazole 500G 580元 2014/06/02 A0432 3-氨基-1,2,4-三唑 3-Amino-1,2,4-triazole 25G 118元 2010/06/21 264571000 3-氨基-1,2,4-三氮唑 3-Amino-1H-1,2,4-triazole 95% 100 GR 1025元
  • 能溶于水、乙醇和氯仿,水溶性280g/L(20℃),毒性LD50(mg/kg)：大鼠经口LD50为1100,动物实验有致癌及致畸作用,结晶（水、乙醇或乙酸乙酯析出）
  • 中毒症状:有轻微的刺激作用和很低的全身中毒。
  • {Chemi
  • 灭火剂:干粉、泡沫、砂土
  • 上游原料:硝酸胍 --> 氰胺 --> 氨基胍碳酸氢盐 --> 氨基胍半硫酸盐
  • 下游产品:乐可安
  • 外观性质:无色晶体。
  • Acros Organics:3-氨基-1，2，4-三唑 3-Amino-1H-1,2,4-triazole, 95%(61-82-5)
  • MSDS 信息:氨基三唑(61-82-5).msds
  • 方法一:由水合肼、氨基氰、甲酸经环合而得；或由氨基胍碳酸氢盐与甲酸作用，再加热环合而得；也可以硝酸胍为原料，先在5-15℃温度下与乙酸反应8h，再与草酸作用，最后环合回流5h而得。
  • 海关编码:29339990
  • Alfa Aesar:3-氨基-1,2,4-三唑,96% 3-Amino-1,2,4-triazole, 96%(61-82-5)
  • 职业标准:TWA 0.2 毫克/立方米
  • 图谱信息:3-氨基-1,2,4-三氮唑(61-82-5)核磁图( 13 CNMR) 3-氨基-1,2,4-三氮唑(61-82-5)质谱(MS) 3-氨基-1,2,4-三氮唑(61-82-5)红外图谱(IR2) 3-氨基-1,2,4-三氮唑(61-82-5)核磁图( 1 HNMR) 3-氨基-1,2,4-三氮唑(61-82-5)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • 急性毒性:口服- 大鼠 LD50: 1100 毫克/公斤; 口服- 小鼠 LD50: 14700 毫克/ 公斤
  • 用途二:可作医药中间体。用于合成药物唑嘧胺。
  • 3-氨基-1,2,4-三氮唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0432 3-氨基-1,2,4-三唑 3-Amino-1,2,4-triazole 500G 1640元 2011/04/16 A0432 3-氨基-1,2,4-三唑 3-Amino-1,2,4-triazole 25G 260元 2010/06/21 264571000 3-氨基-1,2,4-三氮唑 3-Amino-1H-1,2,4-triazole 95% 100 GR 1025元
  • Sigma Aldrich:61-82-5(sigmaaldrich)
  • 注意事项:在我国无登记产品，对健康有潜在的危害
  • 急救治疗:目前尚无解毒药，可采取吐根糖浆催吐，12岁以上为30ml，以下减半。呕吐后服活性炭，还可在炭泥中加山梨醇导泻，若病人不清醒，可插管保护呼吸道。
  • TCI Shanghai:3-氨基-1,2,4-三唑 3-Amino-1,2,4-triazole,>;98.0%(T)(61-82-5)
  • 用途三:可作医药中间体,用于合成药物唑嘧胺,唑嘧胺（乐可安）的中间体，曲匹地尔，亦用作除草剂（非选择性）及用于蛋白质中色氨酸的测定。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazines 三嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazoles 三唑
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Method Specific - Analytical Standards
  4. European Community: ISO, DIN and DL 152 - Method Specific
  5. 2000/60/EC - European Community: ISO, DIN and DL 152
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. A - Alphabetic
  5. AM to AQ - A
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. A to C - Enzyme Inhibitors by Enzyme
  7. Catalase - A to C
  1. Analytical & Chromatography 分析化学与色谱
  2. Environmental Endocrine Disruptors
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Casein Kinase II

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