1H-Imidazo(1,2-a)(1,4)benzodiazepin-1-one,2,4-dihydro-6-(2-chlorophenyl)-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-

CAS 61197-73-7 MFCD00868160

化学结构图

61197-73-7
SMILES: CN1CCN(CC1)/C=C1/N=C2CN=C(C3C=C(C=CC=3N2C/1=O)[N+]([O-])=O)C1=CC=CC=C1Cl

化学属性

Mol. FormulaC23H21ClN6O3
Mol. Weight464.95

别名和识别编码

Chemical Name1H-Imidazo(1,2-a)(1,4)benzodiazepin-1-one,2,4-dihydro-6-(2-chlorophenyl)-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-
CAS Number61197-73-7
Synonym (2Z)-6-(2-Chlorophenyl)-2,4-dihydro-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-one Loprazolam RU 31158
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Sedative, hypnotic.

相关文献及参考

  • Agar, J.R., et al.: J. Med. Chem., 20, 1035 (1977),
  • Clark, B.G., et al.: Drugs, 31, 500 (1986),

安全信息

RTECSNI2922476 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 20,1035,1977

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