(E)-2-(3-(Pyrrolidin-1-Yl)-1-(P-Tolyl)Prop-1-En-1-Yl)Pyridine Hydrochloride Hydrate (E)-2-(3-(吡咯烷-1-基)-1-(对甲苯基)丙烷-1-烯-1-基)吡啶盐酸盐水合物

CAS 6138-79-0 MFCD00039044

化学结构图

6138-79-0
SMILES: Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl

化学属性

Mol. FormulaC19H22N2· HCl
Mol. Weight314.85

别名和识别编码

Chemical Name(E)-2-(3-(Pyrrolidin-1-Yl)-1-(P-Tolyl)Prop-1-En-1-Yl)Pyridine Hydrochloride Hydrate
MDL NumberMFCD00039044
CAS Number6138-79-0
Synonym (E)-2-[1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL]PYRIDINE HYDROCHLORIDE (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride (e)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine monohydrochloride 2-(1-(4-甲基苯基)-3-(1-吡咯烷基)-1-丙烯基)吡啶盐酸盐 2-[(1E)-1-(4-Methylphenyl)-3-pyrrolizino-1-propenyl]pyridine·hydrochloride TRANS-2[3-(1-PYRROLIDINYL)-1-P-TOLYLPROPENYL]PYRIDINE HYDROCHLORIDE TRANS-TRIPROLIDINE HYDROCHLORIDE TRIPROLIDINE HCL TRIPROLIDINE HYDROCHLORIDE Triprolidine hydrochloride Triprolidine hydrochloride monohydrate Venen trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride 盐酸曲普利啶 盐酸曲普立定
PubChem Substance ID5284472
Chemical Name Translation(E)-2-(3-(吡咯烷-1-基)-1-(对甲苯基)丙烷-1-烯-1-基)吡啶盐酸盐水合物
EC Number208-985-0
InChIInChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;
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分类

  • {SNA} Antagonists,
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators,
  • {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, GlaxoSmithKline, Histaminergics, Histaminergics - Antagonists, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, T, 生化试剂, 生物活性小分子, 细胞信

相关文献及参考

  • [2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7.
  • [3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.
  • [1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30.
  • [1]. K J Simons, et al. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986 Feb;77(2):326-30.
  • [2]. D L Deal, et al. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. Nov-Dec 1992;20(6):920-7.
  • [3]. Jann-Inn Tzeng, et al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSUT7658000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Packing GroupIII
Storage condition 2-8°C
Hazard Class6.1(b)
UN Number 3249 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCTR** National Center for Toxicology Research Technical Report.  Office of
   Associate Director for Scientific Coordination, Jefferson, Arkansas 72079
   Volume(issue)/page/year: #414/415,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 163 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCTR** National Center for Toxicology Research Technical Report.  Office of
   Associate Director for Scientific Coordination, Jefferson, Arkansas 72079
   Volume(issue)/page/year: #414/415,1991

其他信息

  • MOL 文件:550-70-9.mol

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. GlaxoSmithKline - Approved Therapeutics/Drug Candidates
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. T - Alphabetic
  5. TP - TZ - T
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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